Medrolin - Tablet Mebhydrolin - 50mg 10 Tablet(s) / Strip Opsonin Pharma Limited Indication: Allergic conditions Administration: Should be taken with food. Take during or shortly after meals. Adult Dose: Oral Allergic conditions Adult: 100-300 mg/day. Child Dose: Oral Allergic conditions Child: 10 yr: 100-300 mg/day. Contraindication: Premature infants and neonates. Acute asthmatic attack. Mode of Action: Mebhydrolin is an ethylenediamine derivative antihistamine with antimuscarinic and sedative properties. Precaution: Closed-angle glaucoma; urinary retention, prostatic hyperplasia or pyloroduodenal obstruction; epilepsy. Elderly. Pregnancy. May impair ability to drive or operate machinery. Side Effect: CNS depression; paradoxical stimulation (high doses, children or elderly); headache, psychomotor impairment; dry mouth, thickened respiratory tract secretions, blurred vision; urinary difficulty or retention, constipation, increased gastric reflux; nausea, vomiting, diarrhoea, epigastric pain. Rarely, blood disorders. Convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, depression, confusion, tinnitus, hypotension, hair loss. Potentially Fatal: Anaphylaxis. Interaction: Enhanced sedation with alcohol or other CNS depressants. Additive antimuscarinic effects with MAOIs, atropine, TCAs. May mask warning symptoms caused by ototoxic agents e.g. aminoglycoside antibiotics.