Mannitol 20% IV (OSL) - Infusion Mannitol 20% - 20% 1 500ml bot(s) / 500ml bot OSL Pharma Limited Introduction: Mannitol 20% IV (OSL) is a medicine used in the treatment of acute renal (kidney) failure, cerebral edema (accumulation of excessive fluid in the brain) and to reduce the pressure inside the eyes in a condition called glaucoma. Mannitol 20% IV (OSL) works by removing excess water and also relieves inflammation in the affected areas. It may be used alone or in combination with other medicines. It is administered as an injection under the supervision of a medical professional and should not be self administered. Take this medicine in the dose and duration as advised by your doctor and if... Uses of Mannitol 20% IV (OSL): Acute renal failureCerebral edema (accumulation of excessive fluid in the brain)Glaucoma Side effects of Mannitol 20% IV (OSL): NauseaVomitingHeadacheDehydration How to use Mannitol 20% IV (OSL): Your doctor or nurse will give you this medicine. Kindly do not self-administer. How Mannitol 20% IV (OSL) works: Mannitol 20% IV (OSL) is an inert substance with high osmotic pressure. It draws water into the kidney, which in turn increases the amount of urine production. Mannitol 20% IV (OSL) is also used to lower the pressure inside the eye or swelling around the brain. What if you forget to take Mannitol 20% IV (OSL)?: If you miss a dose of Mannitol 20% IV (OSL), please consult your doctor. Indication: Chronic bronchitis, Cerebral oedema, Oliguric phase of renal failure, Raised intracranial pressure, Renal function testing, Transurethral prostatic resection Adult Dose: Intravenous Oliguric phase of renal failure Adult: 50-100 g in a 24-hr period by IV infusion. Adjust rate of administration to maintain a urine flow of at least 30-50 mL/hr. Cerebral oedema, Reduction of raised intraocular pressure Adult: 0.25-2 g/kg by IV infusion given over 30-60 minutes. Renal function testing Adult: 0.2 g/kg infused over 3-5 min. Child Dose: Intravenous Edema 0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr Anuria/Oliguria Test dose: 0.2 g/kg IV over 3-5 minutes; not to exceed 12.5 g Discontinue if no diuresis within 2 hr Contraindication: Pulmonary congestion or oedema; intracranial bleeding; CHF; metabolic oedema with abnormal capillary fragility; anuria due to severe renal disease; severe dehydration. Mode of Action: Mannitol increases urinary output by inhibiting tubular reabsorption of water and electrolytes. It raises the osmotic pressure of the plasma allowing water to be drawn out of body tissues. Precaution: Hypervolaemia; urinary tract obstruction; check for signs of fluid and electrolyte imbalance. Should not be administered with whole blood. Pregnancy, lactation. Side Effect: Fluid and electrolyte imbalance; acidosis (with high doses). Nausea, vomiting, thirst; headache, dizziness, convulsions, chills, fever; tachycardia, chest pain; blurred vision; urticaria and hypotension or hypertension; acute renal failure; skin necrosis; thrombophloebitis. Interaction: Increased nephrotoxicity with ciclosporin.