Lumilast - Cream Roflumilast - 30gm 1 30gm Tube(s) / 30gm Tube Navana Pharmaceuticals Ltd. Introduction: Lumilast is used to prevent chronic obstructive pulmonary disease(COPD), group of lung disorders in which the flow of air to the lungs is blocked and chronic bronchitis. It works by opening the airways and makes breathing easier. Lumilast can be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for... Uses of Lumilast: Chronic obstructive pulmonary disease (COPD) Side effects of Lumilast: HeadacheWeight lossDizzinessInsomnia (difficulty in sleeping)Back painNauseaDiarrheaDecreased appetiteFlu How to use Lumilast: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lumilast may be taken with or without food, but it is better to take it at a fixed time. How Lumilast works: Lumilast works by relaxing the muscles in the walls of the airways. This opens the airways and makes breathing easier. Indication: Chronic obstructive pulmonary disease Adult Dose: Chronic Obstructive Pulmonary Disease Reduction of frequency of exacerbations or worsening of symptoms 500 mcg PO once daily Child Dose: Safety and efficacy not established Contraindication: Roflumilast is contraindicated to patients with a history of hypersensitivity to Roflumilast or any of other ingredients of the tablet and if a patient has moderate to severe liver impairment. Mode of Action: Selective phosphodiesterase (PDE)-4 inhibitor; PDE-4 inhibition leads to accumulation of intracellular cyclic adenosine monophosphate (cAMP) in lung tissue and is thought to be underlying mechanism of action. Precaution: Roflumilast is not a bronchodilator and should not be used for the treatment of a sudden attack of breathlessness. Patients treated with this drug should have their weight monitored regularly. If unexplained or clinically significant weight loss occurs, this should be evaluated, and discontinuation of Roflumilast should be considered. Roflumilast should be given with caution in patients with severe immunological diseases (HIV infection, multiple sclerosis, lupus erythematosus, progressive multifocal leukoencephalopathy and others), severe acute infectious diseases (tuberculosis or acute hepatitis), cancer (except basal-cell carcinoma), and severe impairment of the heart function. Lactation: Probable that roflumilast, its metabolites, or both are... Side Effect: 1-10% Diarrhea (9.5%),Weight loss (7.5%),Nausea (4.7%),Headache (4.4%),Back pain (3.2%),Insomnia (2.4%),Decreased appetite (2.1%),Dizziness (2.1%) 1-10% Abdominal pain (1-2%),Anxiety (1-2%),Depression (1-2%),Dyspepsia (1-2%),Gastritis (1-2%),Muscle spasms (1-2%),Rhinitis (1-2%),Sinusitis (1-2%),Tremor (1-2%),Urinary tract infection (1-2%),Vomiting (1-2%) Frequency Not Defined Suicidality Interaction: Erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine; rifampicin, phenobarb, carbamazepine, phenytoin, theophylline, OC.