Levipil 500 - Tablet Levetiracetam - 500mg 10 Tablet(s) / Strip Sun Pharmaceutical (Bangladesh) Ltd. Introduction: Levipil 500 is an anti-epileptic medicine used to treat seizures (fits) in epilepsy. It can be used alone or along with other medicines. It helps to prevent seizures for as long as you continue to take it. Levipil 500 suppresses the abnormal electrical activity in the brain. You can take it with or without food but try to take it at the same time each day to get the most benefit. The dose will depend on your condition and how you respond to the medicine. Your doctor will advise the right dose for you. It is generally advised as a... Uses of Levipil 500: Epilepsy/Seizures Side effects of Levipil 500: SleepinessDizzinessFatigueHeadacheDecreased appetiteBehavioural changesAggressive behaviorIrritationAgitationNasal congestion (stuffy nose)Infection How to use Levipil 500: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Levipil 500 may be taken with or without food, but it is better to take it at a fixed time. How Levipil 500 works: Levipil 500 is an antiepileptic medication. It works by attaching to specific sites (SV2A) on the surfaces of nerve cells. This suppresses the abnormal activity of the nerve cells in the brain and prevents the spread of electrical signals that cause seizures. Indication: Partial seizures Administration: May be taken with or without food. Oral soln may be taken directly or diluted in a glass of water. Adult Dose: Oral Adjunct in seizures Adult: For partial seizures w/ or w/o secondary generalisation; myoclonic seizures (w/ juvenile myoclonic epilepsy); primary generalised tonic-clonic seizures (w/ idiopathic generalised epilepsy): Initially, 500 mg bid on the 1st day. Adjust dose in increments or decrements of 500 mg bid at 2-4 wk intervals. Max: 1,500 mg bid. Monotherapy for partial seizures with or without secondary generalisation Adult: Recommended starting dose is 250 mg bid, increased to an initial therapeutic dose of 500 mg bid after 2 wk. May further increase by 250 mg bid every 2 wk depending upon response. Max: 1,500 mg bid.... Child Dose: Oral Adjunct in seizures Child: 1 to 6 mth 6 mth <50 kg: Initially, 20 mg/kg daily, may adjust in increments of 20 mg/kg at 2-wk intervals. Max: 60 mg/kg daily. To be given via infusion over 15 min. Renal Dose: Renal impairment: ESRD patients undergoing dialysis: Loading dose of 750 mg, followed by 500-1,000 mg once daily; supplemental dose of 250-500 mg after dialysis. CrCl (ml/min) Dosage Recommendation <30 250-500 mg bid. 30-49 250-750 mg bid. 50-79 500-1,000 mg bid. Contraindication: Hypersensitivity. Mode of Action: Anticonvulsant used in the treatment of partial seizures. The precise mechanism of anticonvulsant effect is unknown. Precaution: Renal and hepatic impairment; pregnancy, lactation; patients undergoing haemodialysis. If psychotic symptoms (eg hallucination) and behavioural symptoms (eg agitation, anxiety) occur, reduce dosage. Abrupt withdrawal may result in increased seizure frequency. May impair ability to drive or operate machinery during initial therapy. Lactation: Excreted in breast milk; not recommended Side Effect: >10% Asthenia (11-15%),Headache (14-19%),Infection (11-15%),Increased blood pressure (17% in children < 4 years),Somnolence (11-15%),Drowsiness (2-23%),Fatigue (10-11%),Anorexia (3-13%),Weakness (9-15%),Nasopharyngitis (7-15%),Cough (2-11%) 1-10% Viral infection (2%),Asthma (2%),Dizziness (5-9%),Nervousness (2-10%),Amnesia (2%),Anxiety (2-3%),Ataxia (3%),Depression (2-5%),Hostility (10%),Paresthesia (2%),Sinusitis (2%),Diplopia (2%),Amblyopia (2%),Conjunctivitis (2-3%),Albuminuria (4%) <1% Abnormal hepatic function tests,Dyskinesia,Eczema,Neutropenia,Decreased hematocrit,Leukopenia,Suicidal tendencies,Hepatitis,Pancreatitis,Bone marrow suppression,Epidermal necrolysis Interaction: Enzyme-inducing antiepiletic drugs.