Leukeran - Tablet Chlorambucil - 2mg 25 Tablet(s) / Box Unknown Introduction: Leukeran is used in the treatment of some cancers of blood and lymphatic system. It may be also used to treat other kinds of cancer, as determined by the doctor. It is used alone or in combination with other cancer medicines. Leukeran should be taken empty stomach, or 1 hour before and 2 hours after a meal. But, try to have it at the same time every day for most benefits. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it... Uses of Leukeran: Blood cancerHodgkin’s disease Side effects of Leukeran: Anemia (low number of red blood cells)Decreased blood cells (red cells, white cells, and platelets)Decreased white blood cell count (neutrophils)Decreased white blood cell countBone marrow suppressionNauseaVomitingDiarrheaMouth ulcer How to use Leukeran: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leukeran is to be taken empty stomach. How Leukeran works: Leukeran is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication. What if you forget to take Leukeran?: If you miss a dose of Leukeran, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Lymphocytic leukemia, non-Hodgkin lymphoma, Waldenstrm macroglobulinemia, polycythemia vera, trophoblastic neoplasms, ovarian carcinoma, nephrotic syndrome, Hodgkin's disease Administration: Should be taken on an empty stomach. Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush. Adult Dose: Chronic Lymphatic (Lymphocytic) Leukemia 0.1 mg/kg/day for 3-6 weeks or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or 0.03-0.1 mg/kg/day continuously Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes Hodgkin's Lymphoma 0.2 mg/kg/day for 3-6 weeks or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response or toxicity observed) monthly or 0.03-0.1... Renal Dose: Renal Impairment <1% (including metabolites) excreted in urine; no dose adjustment required Contraindication: Hypersensitivity. Pregnancy and lactation. Porphyria. Mode of Action: Chlorambucil interferes with DNA replication and RNA transcription by alkylation and cross-linking cellular DNA strands, thus leading to disruption of the nucleic acid function. Precaution: Renal or hepatic dysfunction. Perform blood counts regularly. Seizure disorder, bone marrow suppression. Patient who has received radiation therapy, myelosuppressive drugs or has a depressed baseline leukocyte/platelet count within the previous 4 wk. Increased incidence of acute leukaemias and other secondary malignancies. Lactation: not known if excreted in breast milk; do not nurse Side Effect: >10% Neutropenia (25-33%),Anemia,Leukopenia,Thrombocytopenia Frequency Not Defined Seizures,Hallucinations,Peripheral neuropathy,Nausea,Vomiting,Pulmonary fibrosis,GI effects,Leukemia,Myelosuppression,Hyperuricemia,Infertility,Hepatotoxicity & jaundice,Type I hypersensitivity,Rash,Stevens-Johnson syndrome (rare),Toxic epidermal necrosis (rare),Urticaria,Erythema multiforme (rare),Secondary malignancies Potentially Fatal: Severe bone marrow suppression, carcinogenic and human infertility. Pregnancy Category Note: Pregnancy Category: D Lactation: not known if excreted in breast milk; do not nurse Interaction: Impairs immune response to vaccines, possible infection after admin of live vaccines.