Letrol 2.5 - Tablet Letrozole - 2.5mg 5 Tablet(s) / Strip Renata Limited Introduction: Letrol 2.5 is used alone or with other treatments, such as surgery or radiation, to treat early breast cancer in postmenopausal women. It can also be used as the first line treatment of advanced breast cancer that has spread within the breast or to other areas of the body. Letrol 2.5 is also helpful in the treatment of infertility. It belongs to a class of drugs called aromatase inhibitors, which decreases the amount of estrogen in the body. It can be taken with or without food, but take it at the same time to get the most benefit. It should... Uses of Letrol 2.5: Breast cancerInfertility due to anovulation Side effects of Letrol 2.5: FatigueHypercholesterolemia (high cholesterol)Increased sweating How to use Letrol 2.5: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Letrol 2.5 may be taken with or without food, but it is better to take it at a fixed time. How Letrol 2.5 works: Letrol 2.5 is an aromatase inhibitor. It works by decreasing the amount of estrogen (natural female hormone) produced in the body. This decrease in estrogen can slow down or stop the growth of some breast cancers that need estrogen to grow. In addition, it is also useful in infertility whereby it increases the release of certain hormones to stimulate the release of eggs from the ovaries. What if you forget to take Letrol 2.5?: If you miss a dose of Letrol 2.5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Breast cancer Administration: May be taken with or without food. Adult Dose: Oral Advanced or locally advanced breast cancer ; Adjuvant therapy for postmenopausal women with hormone receptor positive early breast cancer Adult: 2.5 mg once daily. Hepatic impairment: Reduce dose by 50% in patients with cirrhosis and severe hepatic impairment; recommended dose: 2.5 mg on alternate days. Contraindication: Premenopausal women and children; hypersensitivity. Mode of Action: Letrozole competitively binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgen to oestrogen, leading to inhibition of the enzyme and a significant reduction in plasma oestrogen levels. Precaution: Severe renal impairment; severe hepatic impairment; osteoporosis. Caution when driving or operating machinery. Lactation: not known if excreted in breast milk (for post-menopausal women) Side Effect: Hot flushes, arthralgia, nausea, vomiting, fatigue, dizziness, headache, dyspepsia, constipation, diarrhoea, anorexia, alopoecia, increased sweating, rash, peripheral oedema, osteoporosis, musculoskeletal pain, vaginal irritation. Potentially Fatal: Thromboembolic events. Interaction: Plasma levels reduced by tamoxifen.