Laxopride 1 - Tablet Prucalopride - 1mg 10 Tablet(s) / Strip Popular Pharmaceuticals Ltd. Introduction: Laxopride 1 is a prescription medicine used in the treatment of constipation. It increases the release of certain chemical that improves the movement of food inside the intestine and helps to increase gastric emptying of both liquid and solid. Laxopride 1 is taken with or without food in a dose and duration as advised by the doctor. The dose you're given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition... Uses of Laxopride 1: Constipation Side effects of Laxopride 1: HeadacheNauseaDiarrheaAbdominal pain How to use Laxopride 1: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Laxopride 1 may be taken with or without food, but it is better to take it at a fixed time. How Laxopride 1 works: Laxopride 1 indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine. What if you forget to take Laxopride 1?: If you miss a dose of Laxopride 1, skip it and continue with your normal schedule. Do not double the dose. Indication: Chronic idiopathic constipation. Administration: May be taken with or without food. Adult Dose: Oral Chronic idiopathic constipation Adult: 2 mg once daily. Elderly: Initially, 1 mg once daily, may increase to 2 mg once daily if necessary. Hepatic Impairment Severe (Child-Pugh Class C): Initially, 1 mg once daily, may increase to 2 mg once daily if necessary. Renal Dose: Severe (GFR <30 mL/min/1.73 m2): 1 mg once daily. Patient on dialysis: Contraindicated. Contraindication: Intestinal obstruction or perforation, obstructive ileus, active severe inflammatory bowel conditions (e.g. Crohn’s disease, toxic megacolon/megarectum, and ulcerative colitis). Renal impairment requiring dialysis. Pregnancy and lactation. Mode of Action: Prucalopride is a selective 5-HT4 receptor agonist w/ prokinetic effect. It stimulates peristaltic reflex, intestinal secretions, and GI motility. Precaution: Patient w/ history of arrhythmias or ischaemic CV disease, severe and unstable concomitant disease (e.g. cancer, AIDS, neurological or psychiatric, pulmonary, IDDM or other endocrine disroders). Severe hepatic (Child-Pugh Class C) and renal (GFR <30 mL/min/1.73 m2) impairment. Elderly. This drug may cause dizziness and fatigue, if affected, do not drive or operate machinery. Monitoring Parameters: Monitor bowel movement frequency. Side Effect: Nervous: Headache, dizziness, fatigue, malaise, tremors. CV: Palpitations. GI: Nausea, abdominal pain and distention, diarrhoea, vomiting, flatulence, dyspepsia, anorexia, rectal bleeding, gastroenteritis. Genitourinary: Polyuria, pollakiuria. Musculoskeletal: Muscle spasm. Others: Fever. Interaction: May decrease serum concentration of contraceptives (i.e. oestrogens, progestins). May enhance adverse effect of levosulpiride. Increased serum concentration w/ P-glycoproteidefault_image.jpgBCB1 inhibitors. Reduced effect w/ atropine-like substance.