Ketozol Shampoo - Shampoo Ketoconazole 1.9%, 2% - 2% 1 100ml bot(s) / 100ml bot Aristopharma Limited Introduction: Ketozol Shampoo belongs to a group of medicines called antifungals. It is used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, thrush and ringworm. Ketozol Shampoo should be used in the dose and duration as prescribed by your doctor. This medicine should be used regularly to get the maximum benefit from it. Do not use more than you need, it will not clear your condition faster and may only increase the side effects. Skin infections will usually get better after 2 to 4 weeks. Do not use the... Uses of Ketozol Shampoo: Fungal skin infections Side effects of Ketozol Shampoo: Application site burningSkin peeling How to use Ketozol Shampoo: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. How Ketozol Shampoo works: Ketozol Shampoo is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection. What if you forget to take Ketozol Shampoo?: If you miss a dose of Ketozol Shampoo, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Dandruff, Seborrheic dermatitis of the scalp, Pityriasis versicolor Administration: To use the Ketoconazole shampoo, follow these steps: Use a small amount of water to wet the area where Ketoconazole shampoo is to be applied. Apply the shampoo to the affected skin/scalp and a large area around it. Use fingers to rub the shampoo until it forms lather. Leave the shampoo on skin/scalp for 5 minutes. Rinse the shampoo off skin/scalp with water. Adult Dose: Seborrheic Dermatitis Cream: Apply q12hr for 4 weeks or until clear Shampoo: Apply twice weekly for 4 weeks, with at least 3 days between each shampoo Tinea Versicolor Shampoo Wet hair, massage into scalp for 1 min, and rinse Repeat, leaving on scalp for 3 additional min Shampoo twice weekly for 4 weeks, allowing 3 days between each shampoo Tinea Corporis, Tinea Cruris, Tinea Pedis Cream: Apply qDay for 2 weeks (6 weeks for tinea pedis), covering affected area Child Dose: Seborrheic Dermatitis 12 years (shampoo): Apply twice weekly for 4 weeks, with at least 3 days between each shampoo >12 years (cream): Apply to affected area q12hr x4 weeks Contraindication: Known hypersensitivity to ketoconazole or any of the excipients. Mode of Action: Ketoconazole interferes w/ biosynthesis of triglycerides and phopholipids by blocking fungal CYP450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide. Precaution: In patients who have been on prolonged treatment with topical corticosteroids, it is recommended that the steroid therapy be gradually withdrawn over a period of 2 to 3 weeks, while using Ketoconazole 2% shampoo to prevent any potential rebound effect. Avoid contact with the eyes. If the shampoo enters the eyes, rinse immediately with plenty of water. Lactation: Not known if distributed into milk; use caution Side Effect: 1-10% Irritation, severe,Pruritus,Stinging Frequency Not Defined Shampoo Hair loss/alopecia,Irritation,Abnormal hair texture,Scalp pustules,Dry skin,Pruritus,Oiliness/dryness of hair and scalp Interaction: Reduced absorption w/ antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Reduced plasma concentrations w/ rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. May also reduce concentrations of isoniazid and rifampicin. May reduce efficacy of oral contraceptives. May increase serum levels of CYP3A4 substrates e.g. digoxin, oral anticoagulants, sildenafil, tacrolimus. Potentially Fatal: May potentiate and prolong sedative and hypnotic effects of midazolam and triazolam. Increased plasma levels and prolonged QT intervals of astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine which may lead to torsade de pointes. Increased risk of myopathy w/ HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin). Markedly increased plasma levels of nisoldipine. Increased risk of...