Joytrip 300 (4) - Tablet Hyoscine Hydro Bromide - 300mcg 8 Tablet(s) / Box Navana Pharmaceuticals Ltd. Introduction: Joytrip 300 (4) is used in the treatment of pain due to smooth muscle spasm. It relieves cramps in the stomach, intestine, bladder, and ureter. It also be used to relieve the symptoms of Irritable Bowel Syndrome (symptoms include abdominal pain, cramping, bloating, and diarrhea or constipation). Joytrip 300 (4) is given by your doctor or nurse. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may... Uses of Joytrip 300 (4): Pain due to smooth muscle spasm Side effects of Joytrip 300 (4): Blurred visionIncreased heart rateDryness in mouthDiarrheaDilatation of pupil How to use Joytrip 300 (4): Your doctor or nurse will give you this medicine. Kindly do not self administer. How Joytrip 300 (4) works: Joytrip 300 (4) is an anticholinergic medication. It works by relaxing the muscles in the stomach and gut (intestine). It stops sudden muscle contractions (spasms), thereby relieving cramps, pain, bloating, and discomfort. What if you forget to take Joytrip 300 (4)?: If you miss a dose of Joytrip 300 (4), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Motion sickness Adult Dose: Adult: Motion sickness As hydrobromide: 300 mcg 30 mins before journey, then 300 mcg 6 hrly if needed. Max: 3 doses in 24 hr. Child Dose: Children over 12 years: Motion sickness As hydrobromide: 300 mcg 30 mins before journey, then 300 mcg 6 hrly if needed. Max: 3 doses in 24 hr. Children 4-12 years: 1 tablet 30 mins before journey. Maximum 2 tablet in 24 hours. Chidren 3-4 years: 1/2 tab 30 mins before journey. Maximum 1 tablet in 24 hours. Contraindication: Narrow-angle glaucoma, acute haemorrhage, paralytic ileus, tachycardia due to cardiac insufficiency, myasthenia gravis. Mode of Action: Hyoscine competitively blocks muscarinic receptors and has central and peripheral actions. It relaxes smooth muscle and reduces gastric and intestinal motility. Precaution: Hepatic/renal disease, pyloric stenosis, urinary retention, prostatic hyperplasia, psychosis, seizure disorders, ulcerative colitis, coronary artery disease, tachyarrhythmias, heart failure, hypertension. Elderly, children, pregnancy, lactation Side Effect: Flushing, postural hypotension, tachycardia, fibrillation. Rarely psychotic reactions. Dizziness, drowsiness, fatigue, headache, memory loss. Dry skin, erythema, increased sensitivity to light, rash. Bloatedness, constipation, dry throat, dysphagia, nausea, vomiting, xerostomia. Dysuria, urinary retention. Tremor, weakness. Impaired accommodation, blurred vision, cycloplegia, dryness, narrow-angle glaucoma, increased intraocular pain, itching, photophobia, pupil dilation. Dry nose. Decreased diaphoresis, heat intolerance. Ophthalmic: Somnolence, dermatitis, oedema, exudate, follicular conjunctivitis, increased IOP, local irritation, photophobia, vascular and respiratory congestion. Potentially Fatal: CNS depression, coma, circulatory and respiratory failure. Interaction: Additive sedative effects with alcohol or other CNS depressants. Reduced effects with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, tacrine). Potentially Fatal: Effect potentiated by other anticholinergic drugs and TCAs.