Indula - Tablet Misoprostol - 200mcg 10 Tablet(s) / Strip Renata Limited Introduction: Indula is a medicine used for medical abortion (terminating a pregnancy). It is also used for preventing excessive bleeding after delivery. This medicine acts on the uterus and increases its contraction. Indula is given alone or in combination with some other medicine to attain the maximum benefit. It should be taken with food or as your doctor's advice. It should be taken orally, by swallow the tablets whole with a drink of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24 hours to show its action... Uses of Indula: Medical abortionPost-delivery bleeding Side effects of Indula: Menorrhagia (heavy menstrual bleeding)VomitingNauseaUterine contractionsDiarrheaStomach cramp How to use Indula: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Indula is to be taken with food. How Indula works: Indula increases contractions of the uterus to cause abortion. It can also prevent post-delivery bleeding due to poor contraction of the uterus. What if you forget to take Indula?: If you miss a dose of Indula, it is likely that the termination will not be fully effective. Talk to your doctor if you forget to take Indula. Indication: NSAID-induced ulcers, Termination of pregnancy, Benign gastric and duodenal ulcers Administration: Should be taken with food. Adult Dose: NSAID-Induced Ulcer Adult: Benign gastric and duodenal ulceration and NSAID associated ulceration: 800 mcg daily (in 2-4 divided doses) with breakfast or main meals and at bedtime; treatment should be continued for at least 4 weeks and may be continued for up to 8 weeks if required. Prophylaxis of NSAID induced gastric and duodenal ulcer: 200 mcg 2-4 times daily taken with NSAID. If this dose cannot be tolerated, a dose of 100 mcg can be used. Misoprostol should be taken for the duration of NSAID therapy Induction of labor: 100 mcg taken orally. If cervical ripening or active labor... Renal Dose: Renal impairment: Use with caution; peak plasma concentration, half-life, and bioavailability may be increased, but it is not clear whether these increases are of clinical relevance Contraindication: Misoprostol is contraindicated to anyone with a history of allergy to prostaglandins. Women of childbearing potential. Pregnancy and lactation. Mode of Action: Misoprostol, a synthetic prostaglandin E1 analogue, exerts its antisecretory activity by directly acting on specific prostaglandin receptors found on the surface of gastric parietal cells. It exerts its protective effects on the mucosa by replacing the prostaglandins consumed during prostaglandin-inhibiting therapies e.g. NSAIDs. Precaution: In case of prevention and treatment of NSAID induced gastric and duodenal ulcer: Misoprostol is contraindicated in women who are pregnant, and should not be used in women of child bearing potential unless the patient requires NSAID therapy. Women of child bearing potential should be told that they must not be pregnant when Misoprostol therapy is initiated and they must use an effective contraception method while taking misoprostol. Conditions where hypotension might precipitate severe complications e.g. cerebrovascular or CV disease. Inflammatory bowel disease. Patients prone to dehydration. Elderly. Renal impairment. Lactation: Drug is rapidly metabolized in mother to misoprostol acid,... Side Effect: >10% Diarrhea (14-40%),Abdominal pain (13-20%) 1-10% Headache (2%) Frequency Not Defined Anaphylaxis,Anemia,Cardiac dysrhythmia,Chest pain,Flatulence,Gastrointestinal hemorrhage,Hearing loss,Myocardial infarction,Nausea Rupture of uterus,Thromboembolic disorder Interaction: May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids.