Imotil 2 - Capsule Loperamide - 2mg 10 Capsule(s) / Strip Square Pharmaceuticals PLC. Introduction: Imotil 2 is used in the treatment of diarrhea. It should not be used in patients with dysentery (diarrhea with blood). Imotil 2 is taken with or without food in a dose and duration as advised by the doctor. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are headache, nausea, and constipation. Most... Uses of Imotil 2: Diarrhea Side effects of Imotil 2: ConstipationNauseaHeadacheStomach pain How to use Imotil 2: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Imotil 2 may be taken with or without food, but it is better to take it at a fixed time. How Imotil 2 works: Imotil 2 is an anti-diarrhoeal medication. It works by slowing down the contraction of the intestines thereby decreasing the speed at which the contents pass through it. This allows more time for reabsorption of fluids and nutrients, making the stools more solid and less frequent. Indication: Diarrhea Administration: May be taken with or without food. Adult Dose: Acute Diarrhea 4 mg initially, then 2 mg after each loose stool; not to exceed 16 mg/day (8 mg/day for self-medication); discontinue if no improvement seen within 48 hours Chronic Diarrhea 4 mg initially, then 2 mg after each loose stool until controlled, and then 4-8 mg/day in divided doses Traveler's Diarrhea 4 mg after first loose stool, then 2 mg after each subsequent stool; not to exceed 8 mg/day Child Dose: Acute Diarrhea First Day of Treatment 2-6 years (13-20 kg): 1 mg q8hr PO 6-8 years: (20-30 kg): 2 mg q12hr PO 8-12 years (>30 kg): 2 mg q8hr PO Second & Subsequent Doses 0.1 mg/kg PO after each loose stool; not to exceed dose recommended for first 24 hours Chronic Diarrhea 0.08-0.24 mg/kg/day PO divided q12hr Traveler's Diarrhea 12 years: 4 mg after first loose stool, then 2 mg after each subsequent stool; not to exceed 8 mg/day Contraindication: Conditions when inhibition of peristalsis is undesirable (e.g. ileus or megacolon); antibiotic induced colitis; active inflammatory bowel disease; if abdominal distention develops during use; abdominal pain in the absence of diarrhoea. Mode of Action: Loperamide inhibits peristalsis and prolongs transit time by acting directly on intestinal wall muscles. It also reduces faecal volume, increases viscosity and decreases fluid and electrolyte loss.. Slows intestinal motility through opioid receptor; has direct effects on circular and longitudinal muscle;. Precaution: Concomitant specific therapy must be given in those with infectious diarrhoea; hepatic dysfunction; infants; pregnancy, lactation. Lactation: Not known if distributed in breast milk; use caution Side Effect: Abdominal pain, distention, and discomfort; paralytic ileus; constipation, dry mouth, drowsiness, dizziness, fatigue, rash. Potentially Fatal: Toxic megacolon. Interaction: Bioavailability increased by co-trimoxazole, ritonavir, saquinavir. Respiratory depression reported when administered with quinidine. Loperamide increases GI absorption of desmopressin and decreases exposure to saquinavir.