HPC DS Injection - Injection Hydroxyprogesterone Caproate - 500mg/ml 1 1's Ampoule(s) / 1's Ampoule Popular Pharmaceuticals Ltd. Introduction: HPC DS Injection is used to prevent premature labor in pregnant women in order to reduce the risk of giving birth too early (preterm birth). It prevents miscarriage and lower the risk of premature birth in women who have had one premature delivery in the past. HPC DS Injection is administered only by or under the supervision of doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you. The most common side... Uses of HPC DS Injection: Premature Labor Side effects of HPC DS Injection: NauseaItchingDiarrheaHivesNodules How to use HPC DS Injection: Your doctor or nurse will give you this medicine. Kindly do not self administer. How HPC DS Injection works: HPC DS Injection is a progestin (female hormone). It works by modulating the immune response of the mother to prevent rejection of the embryo and allow its attachment to the uterus. This prevents miscarriage and helps lower the risk of premature birth in women who have had one premature delivery in the past. Indication: Preterm Labor, Recurrent miscarriage, Amenorrhoea, Abnormal uterine bleeding, Palliative treatment of advanced, inoperable endometrial carcinoma Administration: IM Administration Inject IM over 1 minute in upper outer quadrant of the gluteus maximus Inject IM over 1 minute in upper outer quadrant of the gluteus maximus The solution if viscous and oilyThe solution if viscous and oily 1-mL vial does not contain preservatives and is for single dose use Once opened, the 5-mL multidose vial must be used within 5 weeks Adult Dose: Intramuscular Preterm Labor Indicated for prevention of preterm labor in a singleton pregnancy for patients aged 16 years or older who have a history of spontaneous preterm birth 250 mg IM qWeek Initiate between the 16th and 20th week of gestation and ending at the 37th week of gestation or birth (whichever is first) Recurrent miscarriage Adult: 250-500 mg wkly during the 1st half of pregnancy. Amenorrhoea; Abnormal uterine bleeding Adult: Single dose of 375 mg; may repeat at 4-wkly intervals if needed. After 4 days of desquamation, or if there is no bleeding within 21 days after admin of... Child Dose: Safety and efficacy not established Renal Dose: Not studied in patients with renal impairment Contraindication: Undiagnosed vaginal bleeding, breast cancer, pregnancy, lactation. Thrombophlebitis, thromboembolic disorders, cerebral apoplexy or a history of these conditions. Markedly impaired liver function. Mode of Action: Hydroxyprogesterone caproate stimulates luteal actions, changes in uterus and vagina as seen in early pregnancy. It also has prolonged uterotrophic effect. Contractile response of the myometrium to oxytocin is inhibited. Precaution: Physical examination is advised prior to starting therapy. Hepatic impairment, mental depression. Monitor blood glucose in diabetic patients. Discontinue treatment upon signs of thromboembolic and thrombotic disorders. Discontinue treatment if unexplained, sudden or gradual, partial or complete loss of vision, protopsis, diplopia or papilledema, retinal vascular lesions or migraine occur. Caution when used in patients with conditions that might be worsened by fluid retention (e.g. asthma, seizure disorders, migraine, cardiac or renal dysfunction). Pregnancy Category Note: No adequate or well-controlled studies in women during first trimester Interaction: Increased clearance when used with enzyme inducers e.g. carbamazepine and phenytoin. May inhibit metabolism of ciclosporin.