Histadyl - Tablet Chlorpheniramine Maleate - 4mg 1 Tablet(s) / Tablet Rephco Pharmaceuticals Ltd. Introduction: Histadyl is an antiallergic medication used in the treatment of various allergic conditions. It provides relief from runny nose, sneezing, itching and watery eyes. Histadyl should be taken with or without food, but take it at the same time every day to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. In case, you have... Uses of Histadyl: Allergic conditions Side effects of Histadyl: Dryness in mouthSleepinessDrowsinessLoss of appetiteNausea How to use Histadyl: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Histadyl may be taken with or without food, but it is better to take it at a fixed time. How Histadyl works: Histadyl is an antiallergic medication. When your body is exposed to an allergen (pollen, animal dander, house dust etc.), it produces a chemical called histamine. This causes watery eyes, runny or blocked nose, sneezing, skin rashes, itching etc. Histadyl works by blocking the action of histamine, thereby relieving these symptoms. What if you forget to take Histadyl?: If you miss a dose of Histadyl, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Urticaria, Sneezing, Watery eyes, Allergic conditions, Anaphylactic shock, Rhinitis, Itching Adult Dose: Oral Adult: 4 mg every 4-6 hr. Max: 24 mg daily. Parenteral Adjunct in the emergency treatment of anaphylactic shock Adult: 10-20 mg IM, SC, or slow IV inj over 1 min. Max dose: 40 mg daily. Child Dose: Oral Child: 1-2 yr: 1 mg bid, 2-5 yr: 1 mg every 4-6 hr, 6-12 yr: 2 mg every 4-6 hr. Max: 6 mg daily (1-5 yr); 12 mg daily (6-12 yr). Parenteral Adjunct in the emergency treatment of anaphylactic shock Child: 87.5 mcg/kg SC 4 times daily Contraindication: Hypersensitivity, Neonates. Mode of Action: Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues. Precaution: Elderly, pylori duodenal obstruction, angle-closure glaucoma, urinary retention, prostatic hyperplasia, epilepsy, renal and hepatic impairment. May affect performance of skilled tasks. BPH, bladder neck obstruction, hypertension. Pregnancy, lactation. Side Effect: CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation. Potentially Fatal: CV collapse and respiratory failure. Pregnancy Category Note: Pregnancy Antihistamine exposure in first trimester not reported to be associated with increased risk of malformations; animal studies not reported; there are no controlled data in human pregnancy; only recommended for use during pregnancy when benefit outweighs risk Lactation Excretion into human milk; the manufacturer recommends that caution be used when administering chlorpheniramine to nursing women; infants should be monitored for irritability or drowsiness; antihistamines may temporarily decrease maternal serum prolactin concentrations when administered prior to nursing infant for the first time Interaction: Potentiates sedative effect of psychotropic drugs e.g. barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Interaction with alcohol could be dangerous (sedation/excitation).