Hexinor 1 - Tablet Trihexyphenidyl Hydrochloride - 1mg 10 Tablet(s) / Strip Beacon Pharmaceuticals PLC Introduction: Hexinor 1 is used with other medicines to treat Parkinson’s disease. It’s also used to treat severe movement side effects caused by certain drugs (drug-induced movemnet disorder). Hexinor 1 should be taken empty stomach as it reduces the side effects of this medicine. It should be taken at the same time each day, this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the... Uses of Hexinor 1: Parkinson's diseaseDrug induced abnormal movements Side effects of Hexinor 1: Dryness in mouthNauseaVomitingConstipationBlurred visionDizzinessUpset stomachHeadacheDifficulty in urinationNervousness How to use Hexinor 1: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hexinor 1 is to be taken empty stomach. How Hexinor 1 works: Hexinor 1 is an anticholinergic medication. It works by decreasing the activity of a chemical messenger (acetylcholine) in the brain. This improves muscle control and reduces stiffness in Parkinson's disease. It also improves movement disorder (restlessness, involuntary movements or muscle spasm) caused by certain other medicines. Indication: Extrapyramidal symptoms, Parkinsonism (postencephalitic, arteriosclerotic & idiopathic) Administration: Should be taken with food. Best taken w/ meals. Take before meals if dry mouth occurs, after meals if drooling/nausea occurs. Take at the same time each day. Adult Dose: Oral Drug-induced extrapyramidal symptoms Adult: 5-15 mg/day PO divided q6-8hr Parkinson Disease Adult: Initially, 1 mg daily, gradually increased at intervals of 3-5 days by increments of 2 mg until 6-10 mg daily in 3-4 divided doses. Maintenance: 5-15 mg/day PO divided q6-8hr Parkinsonism Adult: 5-15 mg/day PO divided q6-8hr Elderly: May require lower doses. Child Dose: Safety and efficacy not established Contraindication: Patients with closed-angle glaucoma, chronic pulmonary disease, sick sinus syndrome, thyrotoxicosis, cardiac failure with tachycardia. Mode of Action: Trihexyphenidyl HCl is a tertiary amine antimuscarinic which exerts a direct inhibitory effect on the parasympathetic nervous system. It also exhibits a direct spasmolytic action on smooth muscle, weak mydriatic, antisialagogue and cardiovagal blocking effects. Precaution: Patient w/ arteriosclerosis, history of drug idiosyncrasy. CV disease, glaucoma, GI obstruction, prostatic hyperplasia and/or urinary stricture. Not intended for treatment of tardive dyskinesia. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair mental or physical abilities e.g. operating machinery or driving. Monitoring Parameters Perform gonioscopic examination prior to initiation of therapy. Monitor intraocular pressure at regular intervals during prolonged treatment. Side Effect: >10% Anticholinergic side effects (30-50%), Rash <1% Suppurative parotitis,Hallucination,Paralytic ileus Interaction: Increased antimuscarinic side effects w/ phenothiazines, clozapine, antihistamines, disopyramide, nefopam and amantadine. Synergistic effect when concomitantly used w/ TCAs. Concurrent admin w/ MAOIs may cause dry mouth, blurred vision, urinary hesitancy or retention and constipation. May antagonise effect of metoclopramide and domperidone on GI function. Reduced absorption of levodopa. May antagonise effect of parasympathomimetics.