Gynepro - vaginal_suppository Metronidazole + Neomycin Sulphate + Nystatin + Polmyxin B Vag prep - 200mg+35000IU+35000IU+100000IU 6 Suppository(s) / Strip Square Pharmaceuticals PLC. Indication: Vaginal trichomoniasis, Vaginal leucorrhoea, Bacterial or fungal vaginal infection Adult Dose: Per Vagina: One suppository to be inserted into vagina at bedtime for 12 days. As Vag Capsule: 100 mg every night for 7-14 days. Contraindication: Contraindicated in patients who are hypersensitive to any component of this product. Mode of Action: Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes. Nystatin, a polyene antifungal, binds to ergosterol in the fungal cell membrane. This binding affects the cell wall permeability allowing leakage of cellular contents. Polymyxin B disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids. Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits... Precaution: Caution should be taken in case of renal impaired patients. Side Effect: Skin rash and urticaria, local irritation and sensitisation may occur rarely.