Glucerin - Tablet Diacerein + Glucosamine Sulphate - 50mg+750mg 1 Tablet(s) / Tablet Astra Biopharmaceuticals Ltd. Indication: Rheumatoid arthritis, Osteoarthritis, Chronic low back pain Administration: Should be taken with food. Take w/ or immediately after meals. Adult Dose: Oral Osteoarthritis Adults: 1 tablet twice daily Child Dose: Oral Osteoarthritis Children over 12 years and older: 1 tablet twice daily Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <30 25 mg daily. Contraindication: Absorption of Diacerein is reduced if taken with aluminium and/or magnesium hydroxide antacid. Diacerein also increases risk of diarrhea if taken with laxatives, antibiotics. Avoid co-administration with fibers and phytic acids. Diacerein has shown hypersensitivity to anthraquinone derivatives. Mode of Action: Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1. Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage. Precaution: Caution should be practiced when administering Diacerein + Glucosamine Sulphate in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Diacerein + Glucosamine Sulphate complete blood count, liver function and urinalysis should be monitored regularly. Side Effect: Diarrhea, constipation, epigastric pain, heart burn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine. Interaction: Diacerein: Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates. Glucosamine: May reduce effect of antidiabetic agents, doxorubicin, etoposide, tenoposide. May enhance anticoagulant activity of warfarin.