G-Lomustin - Capsule Lomustine - 10mg 1 Capsule(s) / Capsule Gonoshasthaya Pharmaceuticals Ltd. Introduction: G-Lomustin is used in the treatment of different kinds of cancers. It may be also used to treat other conditions, as determined by the doctor. G-Lomustin should be taken on an empty stomach, but try to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very... Uses of G-Lomustin: Brain tumorLung cancerHodgkin’s diseaseMalignant melanoma Side effects of G-Lomustin: NauseaVomitingStomatitis (Inflammation of the mouth)Hair lossDecreased white blood cell count How to use G-Lomustin: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. G-Lomustin is to be taken empty stomach. How G-Lomustin works: G-Lomustin is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication. What if you forget to take G-Lomustin?: If you miss a dose of G-Lomustin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Brain tumours, Hodgkin's disease, Lung cancer, Malignant melanoma Administration: Should be taken on an empty stomach. Take on an empty stomach. May be taken at bedtime to reduce occurrence of nausea. Adult Dose: Oral Brain tumours; Hodgkin's disease, resistant or relapsed; Malignant melanoma; Lung cancer Adult: 100-130 mg/m2 as a single dose every 6 wk. Adjust dose according to platelet and leukocyte counts. Compromised marrow function: 100 mg/m2 as a single dose every 6 wk. Child Dose: Oral Brain tumours; Hodgkin's disease, resistant or relapsed; Malignant melanoma; Lung cancer Child: 75-150 mg/m2 as a single dose every 6 wk. Readjust dose according to platelet and leukocyte counts. Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation 10-50 Admin 75% of normal dose. <10 Admin 25-50% of normal dose. Contraindication: Pregnancy and lactation. Mode of Action: Lomustine inhibits the synthesis of DNA and RNA via alkylation although carbamoylation and modification of cellular proteins may also be involved. Precaution: Monitor CBC with differential platelet count wkly for at least 6 wk after a dose. Periodically perform pulmonary function studies and LFTs. Lactation: Unknown if metabolites present in breast milk; avoid nursing during treatment and for 2 weeks after final dose Side Effect: >10% Nausea (54%),Vomiting (54%) 1-10% Neurotoxicity,Myelosuppression (delayed 4-5 weeks) Frequency Not Defined Ataxia,Lethargy,Disorientation,Stomatitis,Mucositis,Pulmonary fibrosis (rare),Pulmonary toxicity,Elevated LFTs,Leukemia,Renal toxicity,Hepatic toxicity,Infertility,Alopecia,Optic atrophy (rare) Potentially Fatal: Delayed bone marrow suppression and permanent marrow damage following prolonged use. Interaction: Increased levels/effects with CYP2D6 inhibitors.