Folac 5 - Tablet Folic Acid - 5mg 10 Tablet(s) / Strip Ambee Pharmaceuticals Ltd. Indication: Anemia, Nutritional supplement, Folic acid deficiency, Megaloblastic anemia, Neural tube defect Administration: May be taken with or without food. Adult Dose: Oral Folate-deficient megaloblastic anaemia Adult: 5 mg daily for 4 mth, up to 15 mg daily in malabsorption states. Continued dosing at 5 mg every 1-7 days may be needed in chronic haemolytic states, depending on the diet and rate of haemolysis. Prophylaxis of megaloblastic anaemia in pregnancy Adult: 0.2-0.5 mg daily. Prophylaxis of neural tube defect in pregnancy Adult: 4 or 5 mg daily starting before pregnancy and continued through the 1st trimester. As supplement for women of child-bearing potential Adult: 0.4 mg daily. Child Dose: Folic Acid Deficiency Infants: 15 mcg/kg/day or 50 mcg/day 1-10 years: 1 mg/day initially, then 0.1-0.4 mg/day Contraindication: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency. Mode of Action: Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy. Precaution: Treatment resistance may occur in patients with depressed haematopoiesis, alcoholism, deficiencies of other vitamins. Neonates. Lactation: Drug enters breast milk; safe for nursing Side Effect: Bronchospasm,Erythema,Malaise,Pruritus,Rash,Slight flushing Pregnancy Category Note: Pregnancy category: A Lactation: Drug enters breast milk; safe for nursing Interaction: Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.