Florest 50 - Tablet Fluvoxamine Maleate - 50mg 10 Tablet(s) / Strip Everest Pharmaceuticals Ltd. Introduction: Florest 50 is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is prescribed to treat depression, where it helps to make you feel better. This medicine is also used to treat people with obsessive-compulsive disorder. Florest 50 can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and increase it gradually. Do not change the dose or stop taking it without... Uses of Florest 50: DepressionObsessive-compulsive disorder Side effects of Florest 50: Delayed ejaculationDrowsinessErectile dysfunctionLow sexual desireNauseaVomitingDryness in mouthFatigueIncreased sweatingIndigestionInsomnia (difficulty in sleeping)Loss of appetiteNervousnessTremor How to use Florest 50: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Florest 50 may be taken with or without food, but it is better to take it at a fixed time. How Florest 50 works: Florest 50 is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of obsessive-compulsive disorders. What if you forget to take Florest 50?: If you miss a dose of Florest 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Major depressive disorder, Anxiety disorders, Depression, Panic disorder, Obsessive-compulsive disorder, Posttraumatic stress disorder Administration: May be taken with or without food. Adult Dose: Oral Obsessive compulsive disorder Adult: 50 mg once daily; may increase by 50 mg every 4-7 days. Daily doses >100 mg should be given in 2 divided doses. Max: 300 mg daily. Elderly: Initial 25mg once daily. Depression Adult: Initially, 50-100 mg daily, may increase gradually up to 300 mg daily, if necessary. Doses >150 mg should be given in 2 or 3 divided doses. Hepatic impairment: Decrease dose Child Dose: Oral Obsessive compulsive disorder Child: >8 yr: 25 mg once daily, may increase by 25 mg every 4-7 days. Doses >50 mg should be given in 2 divided doses. Reassess if no improvement after 10 wk of treatment. Max: 200 mg daily. Contraindication: Hypersensitivity. Not to be used with thioridazine, terfenadine, astemizole, cisapride, pimozide, aloestron, tizanidine. Lactation. Mode of Action: Fluvoxamine, derived from aralkylketone, inhibits the re-uptake of serotonin in brain neurons. Precaution: History of mania or seizures; liver dysfunction; presence of depressive symptoms; smokers. Treatment with MAOI should only be started at least 2 wk after stopping fluvoxamine treatment. Increased risk of suicidal ideation and behaviour when used in children, adolescents and young adults <24 yr. Pregnancy, elderly; operating hazardous machinery; withdraw gradually. Monitor prothrombin time in patients who are taking oral anticoagulants concurrently. Lactation Present in breast milk; avoid Side Effect: >10% Nausea (40%),Headache (22-35%),Somnolence (22-27%),Weakness (14-26%),Insomnia (20-35%),Diarrhea (11-18%),Dizziness (11-15%),Xerostomia (10-14%),Anorexia (6-14%),Abnormal ejaculation (8-11%) 1-10% Pain (10%),Dyspepsia (8-10%),Constipation (4-10%),Decreased libido (2-10%),Upper respiratory infections (9%),Anxiety (5-8%),Tremor (5-8%),Sweating (6-7%),Vomiting (4-6%),Abdominal pain (5%),Myalgia (5%),Abnormal taste (2-5%),Bruising (4%),Abnormal dreams (3%),Abnormal thinking (3%),Chest pain (3%),Palpitation (3%),Agitation (2-3%),Vasodilation (2-3%),Hypertension (1-2%),Increased LFTs (1-2%),Weight change (1-2%),Manic reaction <1% Activation of mania/hypomania, seizures (discontinue),Sinusitis Frequency Not Defined Edema,Amnesia,Apathy,Asthenia,Malaise,Nervousness,Dry mouth,Myoclonus,Cough Pregnancy Category Note: Pregnancy Prolonged experience with fluvoxamine in pregnant women over decades, based on published observational studies, have not identified a clear drug-associated risk of major birth defects or miscarriage; there are risks associated with untreated depression in pregnancy and risks of persistent pulmonary hypertension of newborn (PPHN) and poor neonatal adaptation with exposure to selective serotonin reuptake inhibitors (SSRIs), including fluvoxamine, during pregnancy Women who discontinue antidepressants during pregnancy are more likely to experience a relapse of major depression than women who continue antidepressants; consider risk of untreated depression when discontinuing or changing treatment with antidepressant medication during pregnancy and postpartum... Interaction: Co-admin with fluvoxamine may increase carbamazepine toxicity and serum levels of theophylline. Lithium enhances the serotonergic effects of fluvoxamine. Anticoagulants may require dosage adjustments. Diltiazem with fluvoxamine may lead to bradycardia. Avoid alcohol. Potentially Fatal: Fluvoxamine should not be used in combination with MAOIs, or within 14 days of discontinuing treatment with MAOIs.