Flexerin - Tablet Cyclobenzaprine Hydrochloride - 10mg 1 Tablet(s) / Tablet Somatec Pharmaceuticals Ltd. Introduction: Flexerin is a muscle relaxer. It provides relief from the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, stiffness, and muscle spasms. Flexerin should be taken with food. This will prevent you from getting an upset stomach. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as this will make the medicine less effective. Some common side effects of this medicine include sleepiness, dryness in mouth, tiredness, and headache. If any... Uses of Flexerin: Muscle relaxation Side effects of Flexerin: SleepinessDryness in mouth How to use Flexerin: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Flexerin is to be taken with food. How Flexerin works: Flexerin is a muscle relaxant. It works on the centres in the brain and spinal cord to relieve muscle stiffness or spasm without reduction in strength. This improves pain and movement of muscles. What if you forget to take Flexerin?: If you miss a dose of Flexerin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Fibromyalgia, Muscle spasm Adult Dose: Oral Painful muscle spasm associated with musculoskeletal conditions Adult: 5 mg tid, may increase to 10 mg tid if needed. Treatment should not last more than 2-3 wk. Max: 60 mg. Elderly: Initiate with 5 mg with less frequent dosing. Max Dosage: 60 mg. Hepatic impairment: MIld: Start with 5 mg dose with less frequent dosing. Moderate to severe: Not recommended. Child Dose: Muscle Spasm Oral 15 years: 5 mg PO q8hr; may increase dose to 10 mg PO q8hr PRN Contraindication: Recent MI, arrhythmias, severe liver disease. Mode of Action: Cyclobenzaprine, a centrally-acting skeletal muscle relaxant, is structurally related to tricyclic antidepressants, thus they share similar properties. It acts on the brain stem, decreasing tonic-somatic motor activities influencing both the ? and ? motor systems. It is used as an adjunct in the symptomatic treatment of painful muscle spasms associated with musculoskeletal conditions. Precaution: Cardiac disease, history of epilepsy, hepatic impairment, hyperthyroidism, pheochromocytoma, history of mania, psychoses, close-angle glaucoma, history of urinary retention, concurrent electroconvulsive therapy, diabetes. Pregnancy and lactation; elderly, child. Unsafe for use in patients with porphyria. Avoid abrupt withdrawal. May cause drowsiness; do not drive or operate machinery. Treatment for more than 2-3 wk is not recommended. Lactation: Excretion in milk unknown; use with caution Side Effect: >10% Drowsiness (up to 39% immediate-release),Dry mouth (21-32%),Dizziness (3-11%) 1-10% Pharyngitis (1-3%),Headache (1-5%),Fatigue (6%),Palpitations (6%),Bad taste in mouth (1-6%),Indigestion (4%),Blurred vision (3%),Constipation (1-3%),Asthenia (1-3%),Confusion (1-3%),Nausea (1-3%),Nervousness (1-3%) <1% Arrhythmia,Hypotension,Palpitation,Syncope,Tachycardia,Vasodilation,Cardiac dysrhythmia (rare),Cholestasis (rare),Hepatitis,Jaundice,Anaphylaxis (rare),Immune hypersensitivity reaction Pregnancy Category Note: Pregnancy Available data from case reports with use in pregnancy have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes Lactation There are no data on presence of drug in either human or animal milk, the effects on a breastfed infant, or effects on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Interaction: Plasma concentration may be increased with the use of cimetidine, diltiazem, disulfiram, methylphenidate, ritonavir, and verapamil. Side-effects are increased by adrenaline, amiodarone, general anesthetics, SSRIs, antihistamines, antimuscarinics, antipsychotics, anxiolytics and hypnotics, clozapine, disopyramide, diuretics, flecainide, MAOIs, moclobemide, moxifloxacin, nefopam, nicorandil, noradrenaline, phenothiazine, pimozide, procainamide, propafenone, quinidine, selegiline, sibutramine, sotalol, terfenadine, thioridazine, and tramadol. Effects of adrenergic neurone blockers, clonidine, barbiturates, nitrates, and primidone are reduced while effects of baclofen, opioid analgesics, and thyroid hormones are enhanced with concomitant use of cyclobenzaprine. Carbamazepine and rifampicin may increase metabolism of cyclobenzaprine. Effects may be antagonized by oestrogens. Avoid use with brimonidine, entacapone,...