Fimoxyl 500 - Capsule Amoxicillin - 500mg 15 Capsule(s) / Strip Synovia Pharma PLC. Introduction: Fimoxyl 500 is a penicillin-type of antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract (eg. pneumonia), urinary tract, skin and soft tissue, and typhoid fever. Fimoxyl 500 is also used to prevent infection of the heart valves (bacterial endocarditis) in people with pre-existing heart disease. Additionally, it helps to eliminate a bacteria known as H. pylori in people with peptic ulcer disease. It is a broad-spectrum antibiotic that fights and stops the growth of many types of bacteria. This medicine is best taken with a meal... Uses of Fimoxyl 500: Bacterial infections Side effects of Fimoxyl 500: RashVomitingAllergic reactionNauseaDiarrhea How to use Fimoxyl 500: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Fimoxyl 500 may be taken with or without food, but it is better to take it at a fixed time. How Fimoxyl 500 works: Fimoxyl 500 is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive. Indication: Adult: PO Susceptible infections 250-500 mg 8 hrly. Uncomplicated gonorrhoea W/ probenecid: 3 g as a single dose. Dental abscesses 3 g, repeat once 8 hr later. Uncomplicated acute UTI 3 g, repeat once 10-12 hr later. Prophylaxis of endocarditis 2 or 3 g as a single dose, 1 hr before dental procedure. Severe or recurrent resp tract infections 3 g twice daily. H.pylori infection W/ either metronidazole or clarithromycin and a bismuth compound or an antisecretory drug: 500 mg 3 times/day. IV/IM Susceptible infections 500 mg 8 hrly. Listerial meningitis W/ other antibiotics: 2 g 4 hrly for 10-14... Administration: May reduce the efficacy of OC. May increase the effect of anticoagulants. Increased risk of allergic reactions w/ allopurinol. Increased and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin. Adult Dose: Renal and hepatic disease; pregnancy, lactation; infectious mononucleosis. Lactation: Excreted in breast milk, use caution Renal Dose: Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis. Contraindication: Child: PO Standard dose: 40–45 mg/kg/day q8-12h High dose: 80–90 mg/kg/day, max 4 g/day q12h 150 mg/kg/day div q8h for penicillin-resistant S pneumoniae otitis media Mode of Action: May be taken with or without food. May be taken w/ meals for better absorption & to reduce GI discomfort. Precaution: Bacterial infections, Pharyngitis, Acute otitis media, Acute bacterial sinusitis, Endocarditis, Anthrax, Chlamydial cervicitis, Chlamydial urethritis, Lyme disease, Dental abscess, Salmonellosis,Typhoid fever, Acute Uncomplicated gonorrhea, Infections of the Lower Respiratory Tract, Skin and Skin Structure, Genitourinary Tract, Ear, Nose, Throat Side Effect: Renal impairment: Patients on haemodialysis should receive 250-500 mg every 24 hr and an additional dose during and after each dialysis session. CrCl (ml/min) 10-30 250-500 mg every 12 hr. <10 250-500 mg every 24 hr. Pregnancy Category Note: Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis. Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis. Interaction: Hypersensitivity