Fezifol TR - Capsule Ferrous Sulphate + Folic Acid + Zinc - 150mg+500mcg+22.5mg 1 Capsule(s) / Capsule United Chemicals & Pharmaceuticals Ltd. Indication: Iron, Zinc & Folic acid deficiency Administration: For maximum absorption take on empty stomach, but may take with or after meals to minimize GI irritation Adult Dose: Adults: 1-2 capsule daily. Contraindication: Contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency. Mode of Action: Iron: Essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis; also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin. Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy. Zinc: Cofactor in over... Precaution: Care should be taken in patients who may develop iron overload, such as those with haemochromatosis, haemolytic anaemia or red cell aplasia. Iron chelates with tetracycline and absorption may be impaired. Side Effect: Generally well tolerated. However, a few allergic reactions may be seen. Interaction: Concurrent admin with antacids/H2 antagonists may reduce absorption of iron. Chloramphenicol may delay response to iron. Iron may reduce the absorption of levodopa, methyldopa and penicillamine when given together. Absorption may be reduced when used with quinolones or tetracyclines.