Duphaston 10 - Tablet Dydrogesterone - 10mg 20 Tablet(s) / Box Unimed Unihealth Pharmaceuticals Ltd. Introduction: Duphaston 10 is used to treat female infertility, various menstrual problems including painful, or irregular periods, Premenstrual syndrome (PMS) and endometriosis. It helps to restart periods that have stopped before the menopause and to prevent unusually heavy period. Duphaston 10 should be taken as your doctor advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this medicine for as long as it is prescribed for you. The most... Uses of Duphaston 10: Female infertilityPain during menstruationPremenstural syndrome (PMS)Abnormal uterine bleedingEndometriosisAmenorrhea Side effects of Duphaston 10: HeadacheNauseaBreast pain How to use Duphaston 10: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duphaston 10 may be taken with or without food, but it is better to take it at a fixed time. How Duphaston 10 works: Duphaston 10 is a progestin (female hormone). It works by regulating the healthy growth and normal shedding of the womb lining. This action helps re-establish a regular menstrual cycle in conditions where a lack of progesterone causes menstrual problems, such as in premenstrual syndrome, painful or absent menstrual periods, and endometriosis. It also helps in the treatment of infertility by stimulating the womb lining to prepare for a pregnancy. Indication: Endometriosis, Miscarriage, Menstrual disorders, Infertility, Dysmenorrhea, Dysfunctional uterine bleeding, Premenstrual syndrome, Hormone replacement therapy Administration: May be taken with or without food. Adult Dose: Oral Endometriosis Adult: 10 mg bid-tid cyclically or continuously. Recurrent miscarriage Adult: 10 mg bid given cyclically until conception, then continuously until wk 20 of pregnancy, after which dose may be gradually reduced. Menstrual disorders Adult: 10 mg bid in a cyclical regimen. Threatened miscarriage Adult: Initially, 40 mg followed by 10 mg or more every 8 hr, continued for a wk after symptoms are relieved. Reduce dose gradually after that unless symptoms return. Infertility Adult: 10 mg bid. Endometrial protection during menopausal hormonal replacement therapy Adult: 10 mg 1-2 times daily in a cyclical regimen or 5 mg daily. Contraindication: Hypersensitivity; pregnancy. Undiagnosed abnormal vag bleeding, thromboembolic disorders, history or existing cerebrovascular or coronary artery disease, missed or incomplete abortion, known or suspected carcinoma of the breast or genital organs, severe hepatic dysfunction, as a diagnostic test for pregnancy. Mode of Action: Dydrogesterone is a progestogen structurally related to progesterone. However, unlike progesterone, it does not induce an increase in temp nor inhibit ovulation and may be preferred over other progestational agents when contraceptive effect is not required. It does not have oestrogenic or androgenic properties. Precaution: Monitor closely for loss of vision, proptosis, diplopia, migraine, signs and symptoms of embolic disorders. CVD or renal impairment, epilepsy, asthma, other conditions which may be aggravated by fluid retention. Lactation. Side Effect: Dizziness, nausea, headache, fatigue, emotional lability, irritability; abdominal pain and distention; muskuloskeletal pain. Interaction: Carbamazepine, griseofulvin, phenobarbital, rifampicin enhances the clearance of progestogens.