Desol - Syrup Desloratadine - 2.5mg/5ml 1 60ml bot(s) / 60ml bot Zenith Pharmaceuticals Ltd. Introduction: Desol belongs to a group of medicines called antihistamines. It is used in the treatment of various allergic conditions. It relieves symptoms like itching, swelling and rashes. Desol may be taken with or without food. The dose may vary depending on what you are taking it for. Take it as it has been prescribed by your doctor. You may need this medicine only on days you have symptoms, or you may need to take it every day to prevent symptoms from happening. If you stop taking it earlier than advised, your symptoms may come back. This medicine is generally very... Uses of Desol: Allergic conditions Side effects of Desol: Sleepiness How to use Desol: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Desol may be taken with or without food, but it is better to take it at a fixed time. How Desol works: Desol is an antihistaminic medication. It treats allergy symptoms such as itching, swelling, and rashes by blocking the effects of a chemical messenger (histamine) in the body. What if you forget to take Desol?: If you miss a dose of Desol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Itching, Sneezing, Watery eyes, Allergic conditions, Runny nose, Hives, Skin rash, Common cold Administration: May be taken with or without food. Adult Dose: Oral Allergic conditions Adult: 5 mg once daily. Hepatic Impairment: Initially, 5 mg every other day. Child Dose: Oral Allergic conditions Child: 12 years or over : 5 mg once daily. Child 6-11 years : 2.5 mg once daily. Child 12 months-5 years : 1.25 mg (2.5 ml syrup) once daily. Child 6 months-11 months : 1 mg (2 ml syrup) once daily. Renal Dose: Initially, 5 mg every other day. Contraindication: Hypersensitivity. Mode of Action: Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils. Precaution: Severe renal or hepatic failure; children <6 mth, elderly, epilepsy, pregnancy and lactation. Lactation: excretion in milk unknown/not recommended Side Effect: >10% Headache (14%),Fever (12%),Irritability (12%),Diarrhea (15%),Upper respiratory infection (11%),Cough (11%) 1-10% Dizziness (4%),Somnolence (2%),Dizziness (4%),Fatigue (2%),Erythema (2%),Macupopular rash (3%),Dysmenorrhea (2%),Urinary tract infection (4%),Bronchitis (6%),Epistaxis (3%) Pregnancy Category Note: Pregnancy The limited available data in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage; there are no adequate and well-controlled studies in pregnant women Reproductive potential There are no data available on human infertility associated with desloratadine Female: There were no clinically relevant effects of desloratadine on female fertility in rats Male: A male specific decrease in fertility occurred at an oral desloratadine dose of ?12 mg/kg in rats (approximately 65 times the RHD); male fertility was unaffected at a desloratadine dose of 3 mg/kg (approximately 10 times the RHD) Lactation Desloratadine... Interaction: Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole).