Depram 25 - Tablet Imipramine Hydrochloride - 25mg 10 Tablet(s) / Strip Square Pharmaceuticals PLC. Introduction: Depram 25 is known as a tricyclic antidepressant. It is used to treat depression and bedwetting in children of age 6 years and above. It is also effective in treating depression that is unresponsive to other treatments. Depram 25 works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided... Uses of Depram 25: DepressionBed-wetting Side effects of Depram 25: Increased heart rateBlurred visionDryness in mouthDifficulty in urinationConstipationOrthostatic hypotension (sudden lowering of blood pressure on standing) How to use Depram 25: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depram 25 may be taken with or without food, but it is better to take it at a fixed time. How Depram 25 works: Depram 25 is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression. What if you forget to take Depram 25?: If you miss a dose of Depram 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Depression, Nocturnal enuresis Administration: May be taken with or without food. Adult Dose: Oral Depression Adult: Initially, 75 mg in divided doses, may gradually increase to 150-200 mg daily as necessary. Max: 300 mg/day. May give in divided doses or single dose HS Maintenance dose: 50-100 mg PO qDay Elderly: 10 mg daily, may gradually increase to 30-50 mg daily. Hepatic impairment: Severe: Contraindicated. Child Dose: Oral Nocturnal enuresis Child: 6-7 yr 20-25 kg: 25 mg; 8-11 yr 25-35 kg: 25-50 mg; >11yr 35-54 kg: 50-75 mg. Doses are given just before bedtime. Max treatment duration: 3 mth. Contraindication: Any degree of heart block or cardiac arrhythmias, recent MI, porphyria, narrow-angle glaucoma, urine retention, mania. Severe hepatic impairment. Childn <6 yr. Concomitant use w/ MAOIs. Mode of Action: Imipramine is believed to increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibition of their reuptake by the presynaptic neuronal membrane. However, additional receptor effects have been found including desensitisation of adenyl cyclase, down regulation of β-adrenergic receptors, and down regulation of serotonin receptors. Precaution: Imipramine should be used cautiously and with close physician supervision in people, especially the elderly, who have benign prostatic hypertrophy, urinary retention, and glaucoma, especially angle-closure glaucoma. The sedative effect is increased when imipramine is taken with other central nervous system depressants, such as alcoholic beverages, sleeping medications, other sedatives, or antihistamines. Imipramine may increase heart rate and stress on the heart. It may be dangerous for people with cardiovascular disease, especially those who have recently had a heart attack, to take this drug or other antidepressants in the same pharmacological class. Older people and persons with a history of... Side Effect: Orthostatic hypotension, HTN, tachycardia, palpitation, MI, arrhythmias, heart block, ECG changes, precipitation of CHF, stroke; confusional states (esp in elderly) w/ hallucinations, disorientation, delusions; anxiety, restlessness, agitation, insomnia and nightmares, hypomania, exacerbation of psychosis; numbness, tingling, paraesthesias of extremities; incoordination, ataxia, tremors, peripheral neuropathy, extrapyramidal symptoms, seizures, altered EEG patterns, tinnitus; dry mouth; rarely, associated SL adenitis; blurred vision, accommodation disturbances, mydriasis, constipation, paralytic ileus, urinary retention, delayed micturition, dilated urinary tract; skin rash, petechiae, urticaria, itching, photosensitization, oedema, drug fever; bone marrow depression, agranulocytosis; eosinophilia, purpura, thrombocytopenia; nausea and vomiting, anorexia, epigastric distress, diarrhoea, peculiar taste, stomatitis, abdominal cramps,... Interaction: Increased plasma levels and effects with quinidine, cimetidine, SSRIs, propafenone, flecainide. Reduced plasma levels with barbiturates, phenytoin. May increase effects of anticholinergic drugs. Severe orthostatic hypotension with altretamine. Causes drowsiness and impaired performance in combination with alcohol. Potentially Fatal: Severe hypertension with adrenaline, noradrenaline and methylphenidate. Reduces hypotensive effects of guanethidine, bethanidine, debrisoquine, bretylium, methyldopa and clonidine. Possible serotonin syndrome with MAOIs, separate admin by 3 wk.