Dementa 5 - Tablet Memantine Hydrochloride - 5mg 10 Tablet(s) / Strip Ziska Pharmaceuticals Ltd. Introduction: Dementa 5 is a medicine used in the treatment of Alzheimer's disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. This medicine works by blocking a chemical messenger involved in the transmission of nerve signals. Dementa 5 is taken by mouth with or without food. However, it is advised to take it at the same time each day to maintain a consistent level of medicine in the blood. If you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course... Uses of Dementa 5: Alzheimer's disease Side effects of Dementa 5: DizzinessHeadacheConfusionSleepinessDiarrheaAbnormal liver function testsBalance disorder (loss of balance)BreathlessnessPulmonary hypertension (high blood pressure)Hypersensitivity How to use Dementa 5: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dementa 5 may be taken with or without food, but it is better to take it at a fixed time. How Dementa 5 works: Dementa 5 is an N-methyl-D-aspartate (NMDA) receptor antagonist. Memory loss in Alzheimer’s disease is due to excessive production of glutamate (chemical messenger) in the brain which is mediated by NMDA receptors. Dementa 5 works by preventing the action of NMDA receptors and regulates the production of glutamate. involved in the transmission of nerve signals. This is how it prevents memory loss in Alzheimer’s disease. What if you forget to take Dementa 5?: If you miss a dose of Dementa 5, skip it and continue with your normal schedule. Do not double the dose. Indication: Alzheimer's dementia. Administration: May be taken with or without food. Adult Dose: Oral Moderate to severe dementia in Alzheimer's disease Adult: As hydrochloride: Initially, 5 mg daily in the morning for the 1st wk; increase dose wkly in steps of 5 mg. Max: 20 mg daily. Wait for at least 1 wk between dose changes. Doses >10 mg/day should be given in 2 divided doses. Suggested titration: 5 mg daily for >1 wk; 5 mg bid for >1 wk; 15 mg daily given in 5- and 10-mg separated doses for >1 wk; then 10 mg bid. Hepatic impairment Mild or moderate (Child Pugh A/B): No dosage adjustment required Severe (Child Pugh C):... Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation 5-29 Max: 10 mg daily. 30-49 10 mg daily (after initial dose of 5 mg daily), if well tolerated for at least 7 days, may increase to 20 mg daily. Contraindication: Hypersensitivity to memantine or components of the formulation. Severe renal impairment. Mode of Action: Memantine, a derivative of amantadine, is a noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist. It affects transmission of glutamate, the primary excitatory neurotransmitter in the CNS. Glutamate may contribute to the pathogenesis of Alzheimer's disease by overstimulating various glutamate receptors resulting in excitotoxicity and neuronal cell death. Precaution: Renal impairment; epilepsy. Pregnancy and lactation. Closely monitor patients with recent MI, uncompensated CHF, uncontrolled hypertension. Predisposition to convulsions; conditions that increase urinary pH. Lactation: Unknown whether drug is excreted into breast milk; use with caution Side Effect: 1-10% Dizziness (7%),Confusion (6%),Headache (6%),Constipation (5%),Cough (4%),Hypertension (4%),Backache (3%),Pain (3%),Somnolence (3%),Syncope (3%),Vomiting (3%),Dyspnea (2%),Fatigue (2%) <1% Acute renal failure,Cerebral infarction,Cerebrovascular accident,Deep venous thrombosis,Hepatitis, liver failure,Intracranial hemorrhage,Neuroleptic malignant syndrome,Seizure (including grand mal),Stevens-Johnson syndrome,Transient ischemic attack Interaction: May increase effects of antimuscarinics and dopaminergics. May reduce effects of antipsychotics and barbiturates. May alter effects of dantrolene, baclofen. Reduced clearance with carbonic anhydrase inhibitors and sodium bicarbonate. Potentially Fatal: Increased risk of adverse effects with amantadine, dextromethorphan or ketamine.