Danflex 50 - Capsule Dantrolene Sodium - 50mg 10 Capsule(s) / Strip Opsonin Pharma Limited Indication: Muscle tightness, muscle cramping (spasms), muscle pain caused by spinal cord injury, stroke, cerebral palsy, multiple sclerosis. Administration: May be taken with or without food. Adult Dose: Oral Spasticity Adult: Initially, 25 mg daily increased gradually at 7-day intervals over 7 wk. Discontinue if no response after 45 days of treatment. Max: 100 mg 4 times daily. Child Dose: Oral Spasticity Child: Initially, 0.5 mg/kg once daily, may increase gradually to 2 mg/kg 3-4 times daily. Max: 100 mg 4 times daily. Contraindication: Active liver disease; acute muscle spasm; patients who use their spasticity to maintain posture or function. Lactation. Mode of Action: Dantrolene has a direct action on skeletal muscle. It uncouples muscular contraction from excitation, probably by interfering with calcium release from sarcoplasmic reticulum. Precaution: Perform LFTs before and during treatment. Increased risk of liver injury in patients >30 yr, female patients especially those on oestrogen therapy, history of liver disease or patients with daily dose >400 mg. Cardiac or pulmonary disorders. Pregnancy. Lactation: enters breast milk/not recommended Side Effect: Fatigue, muscle weakness/pain. GI disturbances, CNS effects, tachycardia, unstable BP, dyspnoea, drowsiness, rashes, pruritus, chills and fever, visual disturbances, dysphagia, speech disturbances; haematuria, crystalluria, urinary frequency, retention and incontinence. Increased serum AST (SGOT), ALT (SGPT), alkaline phosphatase, LDH, BUN, and total serum bilirubin concentrations, Difficult erection, Abnormal hair growth, Aplastic anemia, Anemia, Leukopenia, Lymphoma, Thrombocytopenia Potentially Fatal: Hepatotoxicity, pleural effusion with pericarditis. Pregnancy Category Note: Pregnancy Category: C Lactation: enters breast milk/not recommended Interaction: CNS depressants; oestrogens; calcium-channel blockers. CNS effects enhanced by alcohol or CNS depressants.