Criptine - Tablet Bromocriptine - 2.5mg 30 Tablet(s) / Box Renata Limited Introduction: Criptine is a dopamine agonists and prolactin inhibitors. It is used in the treatment of medical condition occurs as of high level of prolactin such as infertility, or abnormal production of breast milk. Criptine should be taken with food, but take it at the same time every day for better results. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for... Uses of Criptine: High levels of prolactinFemale infertilityAcromegaly Side effects of Criptine: NauseaVomitingHeadacheDizzinessFatigue How to use Criptine: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Criptine is to be taken with food. How Criptine works: Criptine is a dopamine receptor agonist. It decreases the release of prolactin (milk hormone) in the body. Overproduction of this hormone is associated with abnormal production of breast milk as well as suppression of the sexual glands which can cause infertility. Reducing prolactin levels with Criptine can therefore improve these conditions. In acromegaly, it works by lowering the amount of growth hormone in the body. Indication: Parkinson's disease, Galactorrhoea, Hypogonadism, Infertility, acromegaly, Lactation suppression, benign breast and menstrual disorders, Amenorrhea, hyperprolactinaemia . Administration: Should be taken with food. Adult Dose: Adult: PO Parkinson's disease As adjunct to levodopa: 1st wk: 1-1.25 mg at night, 2nd wk: 2-2.5 mg at night; 3rd wk: 2.5 mg twice daily; 4th wk: 2.5 mg 3 times/day, then increase as needed. Maintenance: 10-40 mg/day. Hyperprolactinemia Initial: 1.25-2.5 mg PO qDay May increase by 2.5 mg/day q2-7Days Usual therapeutic dosage 5-7.5 mg/day, ranges from 2.5-15 mg/day Up to 30 mg/day has been used in some patients with amenorrhea &/or galactorrhea Acromegaly (Parlodel) 1.25-2.5 mg PO qHS for 3 days May increase by 1.25-2.5 mg/day at q3-7Days Not to exceed 100 mg/day Adjunct to surgery and radiotherapy... Child Dose: Hyperprolactinemia 11-15 years: 1.25-2.5 mg PO qDay (initially) Maintenance: 2.5-10 mg/day Contraindication: Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease. Pregnancy and lactation. Mode of Action: Bromocriptine is a dopamine D2 and D3-agonist which works by activating postsynaptic dopamine receptors in the tuberoinfundibular and nigrostriatal pathways. It also inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and in endocrinological disorders. Precaution: Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired. Lactation: should not be used during lactation Side Effect: >10% Nausea (49%),Hypotension (30%),Headache (19%),Dizziness (17%) 1-10% Abdominal cramps,Anorexia,Constipation,Dyspepsia,Dysphagia,Epigastric pain,GI hemorrhage,Vomiting,Drowsiness,Fatigue,Faintness,Hallucinations Visual,Insomnia,Lightheadedness,Nighmares,Paranoia,Psychosis,Seizure,Vertigo,Arrhythmias,Bradycardia,Hypertension,MI,Mottled skin,Orthostasis,Vasospasm,Palpitations,Pericardial effusions,Raynaud's syndrome exacertabtion,Syncope,Blepharospasm,BUN increased,Burning discomfort of the eye,Diplopia,Facial pallor,Leg cramps,Nasal congestion,Rash,Urticaria Pregnancy Category Note: Pregnancy Safety of Bromocriptine treatment during pregnancy to the mother and fetus has not been established If pregnancy occurs during Bromocriptine administration, careful observation of these patients is mandatory Prolactin-secreting adenomas may expand and compression of optic/other cranial nerves may occur, emergency pituitary surgery becoming necessary; in most cases, the compression resolves following delivery Reinitiation of Bromocriptine treatment has been reported to produce improvement in the visual fields of patients in whom nerve compression has occurred during pregnancy In patients being treated for hyperprolactinemia, Bromocriptine should be withdrawn when pregnancy is diagnosed Acromegaly, prolactinoma, or Parkinson disease Patients who subsequently... Interaction: Bioavailability increased if given along with erythromycin. Alcohol reduces tolerance to bromocriptine and vice-versa. Effects of antihypertensives may be potentiated. Avoid concurrent psychotropics.