Coversyl Plus - tablet Indapamide + Perindopril Erbumine - 4mg+1.25mg 30 Tablet(s) / Box Servier Bangladesh Operation Introduction: Coversyl Plus is a medicine used to treat hypertension (high blood pressure). It is a combination of two medicines that helps to control blood pressure when a single medication is not effective. It helps to reduce the chances of any future heart attack and stroke. Coversyl Plus should be taken on empty stomach, preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it,... Uses of Coversyl Plus: Hypertension (high blood pressure) Side effects of Coversyl Plus: NauseaDiarrheaStomach painConstipationVomitingHeadacheVertigoDizzinessAltered visionNumbnessRinging in earBreathlessnessIndigestionAllergic reactionSkin rashItchingCrampsFatigue How to use Coversyl Plus: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Coversyl Plus is to be taken empty stomach. How Coversyl Plus works: Coversyl Plus is a combination of two medicines: Perindopril and indapamide which lower blood pressure effectively. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessels so that blood flows more smoothly and the heart can pump blood more efficiently. Indapamide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Indication: Hypertension Adult Dose: Oral Hypertension Adult: 1 tab once daily in the morning. Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <30 Avoid use. 30-60 Dose adjustment may be needed Contraindication: Hypersensitivity. Severe renal impairment (CrCl <30 ml/min), hypokalaemia, severe hepatic impairment or hepatic encephalopathy, history of angioedema associated with treatment with an ACE inhibitor, children. Dialysis patients or patients with untreated decompensated heart failure. Hereditary/idiopathic angioneurotic oedema. Pregnancy and lactation. Mode of Action: Perindopril is an ACE inhibitor, which acts by inhibiting the conversion of angiotensin I to angiotensin II, reducing the activity of the sympathetic nervous system and inhibiting enzyme kininase, which is involved in the conversion of bradykinin and other substances. Indapamide is a sulfonamide derivative with an indole ring. It inhibits the reabsorption of sodium in the cortical dilution segment, thus increasing urinary output, resulting in an antihypertensive effect. Precaution: Impaired renal function, risk of hypotension and electrolyte imbalance. Regular monitoring of renal function and plasma levels of potassium are recommended. Blood glucose levels should be monitored in diabetic patients especially in those with low serum potassium levels. Increased risk of neutropenia/agranulocytosis in immunosuppressed patients. Treatment should be discontinued immediately if there is angioneurotic oedema of the face, extremities, lips, tongue, glottis and/or larynx. Side Effect: Dry cough, headache, bradycardia, dizziness, asthenia, hypokalaemia and orthostatic hypotension. GI effects such as constipation, dry mouth, nausea, epigastric pain, anorexia, abdominal pain and taste disturbance. Interaction: Additive effect with other antihypertensive agents and diuretics. Increased chance of hypokalaemia with corticosteroids, corticotropin and amphotericin. Potentially Fatal: Increased risk of lithium toxicity. Hypokalaemia enhances digitalis toxicity with cardiac gycosides.