Cotadex - Eye Drop Dexamethasone 0.1% + Tobramycin 0.3% - 0.1%+0.3% 1 5ml drop(s) / 5ml drop Monicopharma Limited Introduction: Cotadex is a prescription medicine having a combination of medicines that is used to treat bacterial eye infections. It stops the growth of bacteria and helps in relieving redness, itching and swelling. Cotadex is to be used only in the affected eye in the dose and duration as advised by the doctor. Wash your hands before using this medicine. It is advised to check the label for directions before use. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening.... Uses of Cotadex: Bacterial infections Side effects of Cotadex: Burning sensation How to use Cotadex: This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. How Cotadex works: Cotadex is a combination of two medicines: Dexamethasone and Tobramycin. Dexamethasone is a steroid which blocks the production of certain chemical messengers (prostaglandins) that make the eye red, swollen and itchy. Tobramycin is an antibiotic. It stops bacterial growth in the eye by preventing the synthesis of essential proteins required by bacteria to carry out vital functions. Indication: Bacterial eye infections, Ocular inflammation, Pink eye Adult Dose: Ophthalmic Ocular inflammation with suspected or confirmed bacterial infection Adult: As Eye Drops: 1-2 drops instilled into the conjunctival sac(s) 4-6 hrly. Dosage may be increased to every 2 hrly during the initial 24-48 hr, decrease frequency gradually as improvement seen. As Ointment: Apply about ½ inch of ointment into the conjunctival sac(s) up to 3-4 times daily. Child Dose: Ophthalmic Ocular inflammation with suspected or confirmed bacterial infection 2 years As Eye Drops: 1-2 drops instilled into the conjunctival sac(s) 4-6 hrly. Dosage may be increased to every 2 hrly during the initial 24-48 hr, decrease frequency gradually as improvement seen. As Ointment: Apply about ½ inch of ointment into the conjunctival sac(s) up to 3-4 times daily. Contraindication: Viral infections of corneal and conjunctiva (e.g. epithelial herpes simplex keratitis, vaccinia, varicella). Mycobacterial or fungal infection of the eye. Mode of Action: Tobramycin, an aminoglycoside antibiotic, has actions similar to that of gentamicin and is active against Staphylococci, Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae and H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus and some Neisseria species. Dexamethasone, a synthetic fluorinated corticosteroid, has mainly glucocorticoid activity and suppresses inflammatory response. Precaution: Pregnancy and lactation. Avoid prolonged use, monitor intraocular pressure routinely. Safety and effectiveness in children <2 yr not established. Lactation: Excretion in milk unknown; use with caution Side Effect: Hypersensitivity reactions, lid itching and swelling, conjunctival erythema, increase in intraocular pressure, glaucoma, optic nerve damage, posterior subcapsular cataract formation and delayed wound healing. Secondary infections especially after prolonged use. Pregnancy Category Note: Pregnancy Category: C Lactation: Excretion in milk unknown; use with caution Interaction: Antagonistic effect w/ neostigmine and pyridostigmine. May potentiate the effect of warfarin and phenindione.