Co-Dopa 110 - Tablet Carbidopa + Levodopa - 10mg+100mg 10 Tablet(s) / Strip Unimed Unihealth Pharmaceuticals Ltd. Introduction: Co-Dopa 110 is a combination of two medicines used to treat Parkinson’s disease. It is one of the most effective medications to relives symptoms of Parkinson’s disease such as tremor, muscle stiffness and difficulty moving. Co-Dopa 110 can be taken without food but it is better to avoid high protein diet and dairy products while taking this medicine. However, it is advised to take it at the same time each day as this helps to maintain consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor and if you have missed... Uses of Co-Dopa 110: Parkinson's disease Side effects of Co-Dopa 110: NauseaVomitingDryness in mouthConstipationDizzinessSleepinessHeadacheAbnormal dreamsAnxietyInsomnia (difficulty in sleeping)Abnormality of voluntary movementsOrthostatic hypotension (sudden lowering of blood pressure on standing) How to use Co-Dopa 110: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Co-Dopa 110 is to be taken empty stomach. Avoid Co-Dopa 110 with high protein meals such as cottage cheese, Swiss cheese, protein powder, eggs and milk. How Co-Dopa 110 works: Co-Dopa 110 is a combination of two medicines: Levodopa and Carbidopa which treats Parkinsonism. Levodopa is a dopamine precursor which gets converted to dopamine, a chemical messenger that controls movement in the brain. Carbidopa is a peripheral decarboxylase inhibitor which prevents breakdown of levodopa allowing it to enter the brain and increase dopamine levels. Indication: Parkinson's disease. Adult Dose: Parkinson Disease & Parkinson like Disorders Adult: PO: Immediate release: 25 mg/100 mg q8hr or 10 mg/100 mg PO q6-8hr initially; levodopa may be increased by 100 mg/day every 1-2 days Carbidopa should be 70-100 mg/day but not to exceed 200 mg/day; levodopa not to exceed 800 mg/day CR tablet: 50 mg/200 mg PO q12hr initially; may be increased up to 1600 mg/day of levodopa; doses must be given at least 6 hours apart Hepatic impairment: Safety and efficacy not established; use with caution Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Safety and efficacy not established; use with caution Contraindication: Lactation, narrow angle glaucoma, melanoma, psychosis, severely decompensated endocrine. Mode of Action: Levodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa. Precaution: Heart disease, liver disease, dementia, psychosis, pregnancy, elderly, heart disease. Regular monitoring of renal and hepatic function is reccomended. Lactation: Drug inhibits lactation; use with caution Side Effect: Edema,Agitation, anxiety, ataxia, bruxism, confusion, daytime somnolence decreased attention span, dyskinesia, dystonia, euphoria, insomnia, fainting, fatigue, increased trembling of hands, insouciance, malaise, memory loss, nightmares, nervousness, restlessness, trismus, vivid dreams,Alopecia, hot flushes, increased &/or dark perspiration, skin eruptions,Abdominal pain & discomfort, burning feeling in tongue, constipation, diarrhea, dysgeusia, dry mouth, dysphagia, hiccups, meteorism, sialorrhea, nausea, weight loss,Muscular spasms, muscular cramp,Hematuria, dark urine, incontinence, priapism, urine retention,Blurred vision, diplopia, dilated pupil, oculogyric problems. Potentially Fatal: Severe postural hypotension in elderly. Pregnancy Category Note: Pregnancy category: C Lactation: Drug inhibits lactation; use with caution Interaction: Pyridoxine reverses effects of levodopa. Type-B MAOIs have synergistic effect. Effect reduced by phenothiazines, haloperidol, reserpine, pyridoxine, diazepam, oxazepam, chlordiazepoxide, phenobarbitone. Effects of levodopa enhanced by carbidopa, amantadine, anticholinergics, amphetamine. Effects of sympathomimetic agents enhanced. Potentially Fatal: Enhances hypotensive effects of bethanidine, bretylium, guanethidine. Hypertensive crises with furazolidone or MAO inhibitors.