Cavapro 150 - Irbesartan - 10 Tablet(s) / Strip Unimed Unihealth Pharmaceuticals Ltd. Introduction: Cavapro 150 is a medicine used to treat high blood pressure and heart disease. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Cavapro 150 can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is... Uses of Cavapro 150: Hypertension (high blood pressure) Side effects of Cavapro 150: DizzinessIncreased potassium level in blood How to use Cavapro 150: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cavapro 150 may be taken with or without food, but it is better to take it at a fixed time. How Cavapro 150 works: Cavapro 150 is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently. What if you forget to take Cavapro 150?: If you miss a dose of Cavapro 150, skip it and continue with your normal schedule. Do not double the dose. Indication: Diabetic nephropathy, Hypertension Administration: May be taken with or without food. Adult Dose: Oral Hypertension Adult: 150 mg once daily, may increase to 300 mg once daily if needed. Patient w/ intravascular volume depletion: Initially, 75 mg once daily. Elderly: >75 yr Initially, 75 mg once daily. Diabetic nephropathy in Type 2 diabetes mellitus Adult: Initially, 75-150 mg once daily, may increase to 300 mg once daily if needed. Child Dose: Hypertension 12 years: 150 mg/day PO initially; may be increased to 300 mg/day PO Renal Dose: Renal impairment: Haemodialysis: Initially, 75 mg once daily. Mild-to-severe renal impairment: Dosage adjustment not necessary unless patient is hypovolemic Contraindication: Hypersensitivity; pregnancy and lactation. Mode of Action: Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors. Precaution: Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy. Lactation: Potential harm to nursing infant; discontinue drug, or do not nurse Side Effect: >10% Hyperkalemia (19%) 1-10% Dizziness (10%),Upper respiratory tract infection (URTI) (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%) Pregnancy Category Note: Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D Interaction: May antagonise hypotensive effect and increase risk of nephrotoxicity w/ NSAIDs. May increase serum lithium levels and toxicity. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes. Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).