Carbizol 5 - Tablet Carbimazole - 5mg 10 Tablet(s) / Strip Square Pharmaceuticals PLC. Introduction: Carbizol 5 belongs to a group of medicine called anti-thyroid agents. It is used in the treatment of hyperthyroidism. It reduces the amount of thyroid hormones produced by the thyroid gland. Carbizol 5 may be used alone or in combination with other medicines. It can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the... Uses of Carbizol 5: Hyperthyroidism Side effects of Carbizol 5: Skin rashHeadacheSkin pigmentationPainJoint stiffnessNauseaParesthesia (tingling or pricking sensation)Hair loss How to use Carbizol 5: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Carbizol 5 may be taken with or without food, but it is better to take it at a fixed time. How Carbizol 5 works: Carbizol 5 is an anti-thyroid medication. It works by reducing the amount of thyroid hormones produced by the thyroid gland. Indication: Grave's disease, Hyperthyroidism, Diabetic nephropathy, Preparation for thyroidectomy Administration: May be taken with or without food. Take consistently w/ or w/o meals. Adult Dose: Oral Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth. Hepatic impairment: Severe: Contraindicated. Child Dose: Oral Hyperthyroidism; Adjunct to radio-iodine therapy; Preparation for thyroidectomy Child: 3-17 yr Initially, 15 mg daily, adjusted according to response. Contraindication: Hyperthyroidism due to nodular goitre. Mode of Action: Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase. Precaution: Liver diseases, pregnancy, lactation. Side Effect: Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia. Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre. Interaction: Increased serum levels of theophylline or may develop toxicity. May enhance the effect of anticoagulants. Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid.