Caprolycin - Injection Aminocaproic Acid - 2gm/10ml 1 10ml Ampoule(s) / 10ml Ampoule Pacific Pharmaceuticals Ltd. Introduction: Caprolycin is used to treat bleeding. It helps to prevent bleeding after major heart surgery and it also controls bleeding in thrombocytopenia (accompanying aplastic anemia), liver cirrhosis, urinary bleeding and some types of cancer. Caprolycin works by preventing the breakdown of clots which leads to stoppage of bleeding. This injection must be administered under the supervision of a healthcare professional. You should not take it if you have any known allergy from this injection. The most common side effects may be injection site reactions such as pain, swelling and redness or pain in the muscle, bone or joint. Inform your... Uses of Caprolycin: Bleeding Side effects of Caprolycin: Nasal congestion (stuffy nose)TirednessMusculoskeletal (bone, muscle or joint) painInjection site reactions (pain, swelling, redness) How to use Caprolycin: Your doctor or nurse will give you this medicine. Kindly do not self administer. How Caprolycin works: Caprolycin prevents the breakdown of clots and stops bleeding. What if you forget to take Caprolycin?: If you miss a dose of Caprolycin, skip it and continue with your normal schedule. Do not double the dose. Indication: Intravenous Treatment and prophylaxis of haemorrhage Adult: Initially, 4-5 g as a 2% solution over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. Oral Treatment and prophylaxis of haemorrhage Adult: Initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. Patients with haemophilia undergoing dental extraction Adult: Initially, 6 g immediately after the procedure, followed by 6 g every 6 hr for up to 10 days. Administration: Increased risk of hypercoagulability with OC and oestrogens. Adult Dose: Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; veno-occlusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin with factor IX complex concentrates. Pregnancy and lactation. Lactation: not known whether excreted in breast milk, use caution Renal Dose: Aminocaproic acid inhibits the action of plasminogen activators and, to a lesser extent, it also has some antiplasmin activity. Mode of Action: IV Administration Initial 5 g in 250 mL over 1 hr, each subsequent gram in 50-100 mL at 1 g/hr Rapid injection undiluted into a vein is not recommended Continue for about 8 hr or until bleeding has been controlled Oral May be taken with or without food. May be taken w/ meals to prevent GI upset. Precaution: Haemorrhage, Missed abortion, Hereditary hemorrhagic telangiectasia,Traumatic hyphema, Dental bleeding, Hemophilia A, Postoperative bleeding, Systemic hyperfibrinolysis Side Effect: Renal impairment: Dosage reduction may be required. Pregnancy Category Note: Oedema, headache, malaise, allergic and anaphylactic reactions, anaphylaxis, bradycardia, hypotension, peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, myopathy, myositis, rhabdomyolysis, confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dyspnoea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation. Potentially Fatal: Cardiac and hepatic damage. Interaction: Bleeding due to disseminated intravascular coagulation. Rapid IV administration.