Bn Sterile - Eye/Ear Drops Betamethasone 0.1% + Neomycin Sulphate 0.5% E/E prep - 0.1%+0.5% 1 5ml drop(s) / 5ml drop Asiatic Laboratories Ltd. Introduction: Bn Sterile is a combination of medicine that is used to treat various types of bacterial ear or eye infections. It prevents the growth of the bacteria that cause infection in the eyes or ears. Bn Sterile is to be used as per the label instructions or as suggested by your doctor. This medicine must be applied only to the affected eye or ear and use it regularly to get the most benefit. The course of the medicine should be completed even if you feel better. You must wash your hands before administering the medicine. Do not use it more... Uses of Bn Sterile: Bacterial eye / ear infections Side effects of Bn Sterile: Erythema (skin redness)SwellingItching How to use Bn Sterile: This medicine is for external use only.Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye/ear without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid or ear. Wipe off extra liquid. How Bn Sterile works: Bn Sterile is a combination of two medicines: Betamethasone and Neomycin. Betamethasone is a steroid which blocks the production of certain chemical messengers (prostaglandins) that make the eye/ear red, swollen and itchy. Neomycin is an antibiotic. It stops bacterial growth in the eye/ear by preventing the synthesis of essential proteins required by bacteria to carry out vital functions. Indication: Allergic and inflammatory conditions of the eye & ear, otitis externa, uveitis, marginal keratitis, allergic conjunctivitis, blepharitis, episcleritis Administration: Eye Ointment: Apply ¼ inch long to the lower eye lid 2-3 times daily and/or at night. Adult Dose: Eye, Ear & Nasal Drops: Eye: 1 drop instilled into the eye every one or two hours until control is achieved, when the frequency may be reduced. Ear: 2 or 3 drops instilled into the ear, every two or three hours until control is achieved, when the frequency can be reduced. Nose: 2 or 3 drops instilled into each nostril two or three times daily. Eye Ointment: It should be applied thinly and evenly to the conjunctival sac at night (If eye drops used during day) or 3-4 times daily (if ointment used alone). Contraindication: Viral, fungal, tuberculous or purulent conditions of the eye. Fungal infections of the nose or ear. Use is contra-indicated if glaucoma is present or herpetic keratitis (e.g. dendritic ulcer) is considered a possibility. Use of topical steroids in the latter condition can lead to an extension of the ulcer and marked visual deterioration. Otitis externa should not be treated when the eardrum is perforated because of the risk of ototoxicity. Corticosteroids should not be used in patients with a perforated tympanic membrane. Hypersensitivity to any component of the preparation. Mode of Action: Betamethasone is a corticosteroid which is effective in inflammatory conditions. Neomycin sulfate is a broad spectrum antibiotic. It is bactericidal against many bacteria . Precaution: Topical corticosteroids should never be given for an undiagnosed red eye as inappropriate use is potentially blinding. Treatment with corticosteroid/antibiotic combinations should not be continued for more than 7 days in the absence of any clinical improvement, since prolonged use may lead to occult extension of infection due to the masking effect of the steroid. Prolonged use may also lead to skin sensitisation and the emergence of resistant organisms. Ophthalmological treatment with corticosteroid preparations should not be repeated or prolonged without regular review to exclude raised intraocular pressure, cataract formation or unsuspected infections. Aminoglycoside antibiotics may cause irreversible, partial or... Side Effect: Hypersensitivity reactions, usually of the delayed type, may occur leading to irritation, burning, stinging, itching and dermatitis. Topical corticosteroid use may result in corneal ulceration, increased intraocular pressure leading to optic nerve damage, reduced visual acuity and visual field defects. Intensive or prolonged use of topical corticosteroids may lead to formation of posterior subcapsular cataracts. In those diseases causing thinning of the cornea or sclera, corticosteroid therapy may result in thinning of the globe leading to perforation. Mydriasis, ptosis, epithelial punctate keratitis and glaucoma have also been reported following ophthalmic use of corticosteroids. Cases of corneal calcification have been reported... Pregnancy Category Note: Safety for use in pregnancy and lactation has not been established. There is inadequate evidence of safety in human pregnancy. Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development including cleft palate and intrauterine growth retardation. There may therefore be a very small risk of such effects in the human foetus. There is a risk of foetal ototoxicity if aminoglycoside antibiotic preparations are administered during pregnancy. Interaction: If there is significant systemic absorption, neomycin sulfate may increase the respiratory depressant effects of neuromuscular blockers.