Bisopol A - Tablet Bisoprolol + Amlodipine - 2.5mg+5mg 50 Tablet(s) / Box Euro Pharma Ltd. Introduction: Bisopol A is used to treat hypertension (high blood pressure). This is a combination of two medicines that controls blood pressure when a single medication is not effective. It helps to lower high blood pressure and thus reduces the chances of future heart attack and stroke. "Bisopol A is a medicine used to treat hypertension (high blood pressure). It is a combination of two medicines that effectively controls blood pressure when a single medication is not effective. It helps to lower high blood pressure and thus reduces the chances of future heart attack and stroke. It should be taken empty... Uses of Bisopol A: Hypertension (high blood pressure) Side effects of Bisopol A: SleepinessHeadacheAnkle swellingFlushing (sense of warmth in the face, ears, neck and trunk)Slow heart rateTirednessPalpitationsNauseaEdema (swelling)ConstipationCold extremities How to use Bisopol A: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bisopol A may be taken with or without food, but it is better to take it at a fixed time. How Bisopol A works: Bisopol A is a combination of two medicines: Amlodipine and Bisoprolol, which lowers blood pressure effectively. Amlodipine is a calcium channel blocker which works by relaxing blood vessels while bisoprolol is a beta blocker that works specifically on the heart to slow down the heart rate. Together, they make the heart more efficient at pumping blood throughout the body. Indication: Treatment of mild to moderate hypertension Adult Dose: Oral Adult 1 tablet once daily Contraindication: Cardiogenic shock, overt cardiac failure, second or third degree AV block, and marked sinus bradycardia and known sensitivity to amlodipine/bisoprolol. Mode of Action: Bisoprolol selectively and competitively blocks β1-receptors but has little or no effect on β2-receptors except at high doses. Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina. Precaution: Bisoprolol: Overt congestive cardiac failure, abrupt cessation of therapy, peripheral vascular disease, bronchospastic disease, anesthesia and major surgery, diabetes and hypoglycaemia and thyrotoxicosis. Amlodipine: Severe aortic stenosis, congestive heart failure and hepatic failure This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Side Effect: Edema, headache, increase heart rate, sneezing, fatigue, leg cramps, dry mouth. Other adverse events reported were gastric irritation, angina, asthma, cold extremities, cough, decrease in libido, dizziness, facial flushing, postural hypotension, skin rash, sleep disturbance and vertigo.