Betnesol - Drops Betamethasone 0.1% E/E & Nasal prep - 0.10% 1 10gm tube(s) / 10gm tube Glaxo SmithKline Pharmaceuticals Ltd Introduction: Betnesol belongs to a group of medicines called steroids. It is used to relieve swelling, itchiness, and redness of eyes and ears that may be caused due to infection. It reduces the inflammation by stopping the release of substances that cause the inflammation. Never use Betnesol if the seal is broken before you use it for the first time. Wash your hands before using it and shake the bottle well before each use. Make sure you remove contact lenses if you wear them and wait for at least 15 minutes before putting them back. You should not discontinue using the... Uses of Betnesol: Bacterial eye / ear infections Side effects of Betnesol: Application site irritation How to use Betnesol: This medicine is for external use only.Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye/ear without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid or ear. Wipe off extra liquid. How Betnesol works: Betnesol is a steroid. It works by blocking the production of certain chemical messengers (prostaglandins) that make the eye/ear red, swollen and itchy. What if you forget to take Betnesol?: If you miss a dose of Betnesol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Allergic and inflammatory conditions of the eye, ear & nose. Adult Dose: Adults Eye: 1 or 2 drops to each affected eye every 1 or 2 hours until control is achieved, then the frequency may be reduced. Ear: 2 or 3 drops to each affected ear every 2 or 3 hours until control is achieved, then the frequency may be reduced. Nose: 2 or 3 drops instilled into each nostril 2 or 3 times daily. Child Dose: Children Eye: 1 or 2 drops to each affected eye every 1 or 2 hours until control is achieved, then the frequency may be reduced. Ear: 2 or 3 drops to each affected ear every 2 or 3 hours until control is achieved, then the frequency may be reduced. Nose: 2 or 3 drops instilled into each nostril 2 or 3 times daily. Contraindication: Hypersensitivity; systemic fungal or acute infections. Mode of Action: Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation. Precaution: Uncontrolled diabetes, pregnancy and lactation. Elderly, regular monitoring of patients on long term therapy, withdraw gradually, glaucoma, hypothyroidism, ocular herpes simplex, infants and children. Side Effect: Corneal ulcers, raised IOP and reduced visual acuity. Interaction: Increased hyperglycaemia and hypokalaemia with thiazide diuretics. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Potentially Fatal: Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Enhanced effect in women taking oestrogens or oral contraceptives.