Avil - Tablet Pheniramine Maleate - 22.7mg 15 Tablet(s) / Strip Synovia Pharma PLC. Introduction: Avil is an antiallergic medication. It treats symptoms of severe allergic reactions due to insect bite/sting, certain medicines, hives (rashes, swelling etc). Avil is given as an injection into veins or muscles under the supervision of a doctor. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Sleepiness is the most common side effect of this medicine. Avoid driving... Uses of Avil: Allergic conditions Side effects of Avil: Sleepiness How to use Avil: Your doctor or nurse will give you this medicine. Kindly do not self administer. How Avil works: Avil is an antiallergic medication. It works by blocking the action of a chemical messenger (histamine). This relieves symptoms of severe allergic reactions due to insect bite/sting, certain medicines, hives (rashes, swelling etc). What if you forget to take Avil?: If you miss a dose of Avil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Allergic conditions, Motion sickness, Allergic conjunctivitis, Allergic rhinitis Administration: Should be taken with food. Take after meals. Adult Dose: Oral Allergic conditions Adult: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Elderly: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Prophylaxis of motion sickness Adult: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Take 1st dose at least 30 min before travelling. Child Dose: Oral Allergic conditions Child: Tablet 5-10 yr: Half a 45-mg tablet up to tid; Tablet: Up to 45 mg tid. >10 yr: Syrup: 15-30 mg bid or tid. Max: 3 mg/kg/day. Prophylaxis of motion sickness Child: As maleate: 5-10 yr: Half a 45-mg tablet up to tid; >10 yr: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Take 1st dose at least 30 min before travelling. Contraindication: Symptomatic prostatic hypertrophy; neonates and premature infants. Mode of Action: Pheniramine is an alkylamine derivative with histamine H1-receptor antagonist effects. It also has anticholinergic and moderate sedative effects. Precaution: May impair ability to drive or operate machinery. Has potential for abuse. Narrow angle glaucoma, asthma or severe CV disease. Antiemetic effect may mask signs of other conditions. Pregnancy and lactation. Elderly. Side Effect: Sedation. Hypersensitivity reactions. Lassitude, dizziness, tinnitus, inability to concentrate, incoordination, irritability, insomnia and tremors. Nausea, vomiting, diarrhoea, colic, epigastric pain, anorexia, dryness of mouth and constipation. Urinary retention. Palpitations, headache. Blurred vision, increased intraocular pressure. Muscular weakness. Rarely, blood dyscrasias e.g. agranulocytosis, haemolytic anaemia. Interaction: May mask ototoxicity produced by aminoglycoside antibiotics. Potentially Fatal: Potentiation of CNS depression by alcohol, sedatives, opioids, barbiturates, hypnotics, narcoleptics. May increase antimuscarinic effect of MAOIs, atropine and TCAs.