Aromasin - Tablet Exemestane - 25mg 15 Tablet(s) / Box Janata Traders Introduction: Aromasin is an aromatase inhibitor. It is used in the treatment of breast cancer in women who have gone through menopause. It works by adjusting the level of estrogen and helps in slowing down the growth of cancer cells. Aromasin is also used in combination with medication in early cancer to prevent the risk of coming back. It should be taken with food, but take it at the same time every day to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it... Uses of Aromasin: Breast cancer Side effects of Aromasin: Insomnia (difficulty in sleeping)HeadacheNauseaIncreased sweatingMusculoskeletal (bone, muscle or joint) painFatigue How to use Aromasin: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aromasin is to be taken with food. How Aromasin works: Aromasin is an aromatase inhibitor. It works by lowering the amount of estrogen (natural female hormone) produced in the body. This can lower or stop the growth of some breast cancer cells that need estrogen to grow. What if you forget to take Aromasin?: If you miss a dose of Aromasin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Breast cancer in postmenopausal women Administration: Should be taken with food. Take after a meal. Adult Dose: Oral Advanced or locally advanced breast cancer Adult: In women who are no longer responsive to anti-oestrogen therapy: 25 mg once daily. Contraindication: Hypersensitivity. Premenopausal women. Pregnancy and lactation. Mode of Action: Exemestane is an irreversible selective aromatase inhibitor which acts as a false substrate for the aromatase enzyme, forming an intermediate that binds irreversibly to the active site causing its inactivation. It also lowers circulating oestrogens in estrogen-dependent breast carcinoma. Precaution: Hepatic and renal impairment. Monitor bone mineral density at regular intervals especially in patients at risk of osteoporosis. Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose Side Effect: >10% Fatigue (22%),Nausea (18%),Hot flashes (13%),Depression (13%),Pain (13%),Insomnia (11%) 1-10% Anxiety (10%),Dyspnea (10%),Dizziness (8%),Headache (8%),Edema (7%),Vomiting (7%),Flu-like syndrome (6%),Abdominal pain (6%),Anorexia (6%),Cough (6%),Hypertension (5%),Constipation (5%),Diarrhea (4%) <1% Cardiac failure,Uterine polyps,Endometrial hyperplasia,Gastric ulcer Frequency not defined Hepatitis,Visual disturbances Pregnancy Category Note: Pregnancy Category: X Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose Interaction: May result in reduced plasma levels of exemestane when used with CYP3A4 enzyme inducers. Oestrogen-containing drugs; St. John's wort, black cohosh, dong quai.