Arodex - Tablet Anastrozole - 1mg 10 Tablet(s) / Strip Techno Drugs LTD. Introduction: Arodex is used alone or with other treatments, such as surgery or radiation, to treat early breast cancer in postmenopausal women. It can also be used as the first line treatment of advanced breast cancer that has spread within the breast or to other areas of the body. Arodex belong to a class of drug called aromatase inhibitors, which decreases the amount of estrogen in the body. It should be taken with or without food, but take it at the same time every day to get the most benefit. It should be taken as your doctor's advice. The dose and... Uses of Arodex: Breast cancer Side effects of Arodex: HeadacheMusculoskeletal (bone, muscle or joint) painNauseaOsteoporosisSkin rashWeakness How to use Arodex: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arodex may be taken with or without food, but it is better to take it at a fixed time. How Arodex works: Arodex is an aromatase inhibitor. It works by lowering the amount of estrogen (natural female hormone) produced in the body. This can lower or stop the growth of some breast cancer cells that need estrogen to grow. What if you forget to take Arodex?: If you miss a dose of Arodex, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Oral Advanced or locally advanced breast cancer, Adjuvant treatment in early breast cancer Adult: In postmenopausal women: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr. Hepatic Impairment Mild-to-moderate impairment or stable hepatic cirrhosis: Dose adjustment not necessary Severe hepatic impairment: Not studied Administration: Efficacy decreased by oestrogens. Plasma concentrations decreased by tamoxifen. Adult Dose: Moderate or severe hepatic impairment, hyperlipidaemias. Laboratory test for menopause if status is doubtful. Bone mass density test should be conducted at the start of the therapy and at regular intervals thereafter. Lactation: Unknown whether drug is excreted in milk; not recommended given potential for serious adverse reactions in nursing infants Renal Dose: Anastrozole prevents conversion of androstenedione to estrone and testosterone to oestradiol by inhibiting aromatase, thus leading to significantly reduced serum oestradiol concentrations. Mode of Action: May be taken with or without food. Precaution: Breast cancer, Ovulation induction Pregnancy Category Note: >10% Hot flashes (12-36%),Vasodilation (25-36%),Fatigue (19%),Mood disturbances (19%),Nausea and vomiting (19%),Weakness (16-19%),Arthritis (17%),Pain (17%),Arthralgia (2-15%),Pharyngitis (14%),Depression (13%),Hypertension (2-13%),Bone pain (11%),Increased cough (11%),Osteoporosis (11%),Rash (8-11%) 1-10% Accidental injury (10%),Back pain (10%),Fracture (10%),Headache (10%),Insomnia (10%),Peripheral edema (10%),Dyspnea (8-10%),Abdominal pain (9%),Infection (9%),Lymphedema (9%),Diarrhea (8-9%),Constipation (7-9%),Breast pain (8%),Dizziness (8%),Urinary tract infection (8%),Chest pain (7%),Dyspepsia (7%),Paresthesia (5-7%),Anxiety (6%),Cataracts (6%),Flu syndrome (6%),Sinusitis (6%),Vulvovaginitis (6%),Xerostomia (6%),Breast neoplasm (5%),Bronchitis (5%),Cyst (5%),Diaphoresis (5%),Neoplasm (5%),Vaginal bleeding (5%),Fractures of spine, hip, or wrist (4%),Ischemic cardiovascular disease (4%),Vaginal hemorrhage (4%),Vaginitis (4%),Leukorrhea (3-4%),Deep vein thrombosis (2%),Endometrial cancer (intact uterus at baseline) (2%),Ischemic cerebrovascular event (2%),Weight gain (2%),Lethargy (1%) Interaction: Pregnancy. Hypersensitivity, premenopausal women.