Aloxif - Tablet Raloxifene Hydrochloride - 60mg 1 Tablet(s) / Tablet Incepta Pharmaceuticals Ltd. Introduction: Aloxif is a medicine used in the treatment and prevention of osteoporosis in postmenopausal women. It helps in preventing bone loss that can develop in women after menopause. It makes the bone stronger and lowers the risk of fractures. Aloxif can be taken with or without food. Take it regularly and do not stop taking the medicine even if you get better until that doctor tells you it is alright to stop. Along with taking the medicine, exercise regularly to strengthen muscles around the affected joint and manage your weight. You should also avoid smoking and excessive consumption of alcohol... Uses of Aloxif: Osteoporosis Side effects of Aloxif: Leg crampsPeripheral edemaFlu-like symptomsJoint painSweating How to use Aloxif: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aloxif may be taken with or without food, but it is better to take it at a fixed time. How Aloxif works: Aloxif works like estrogen, a natural female hormone to stop the bone loss that can develop in women after menopause. Indication: Post-menopausal osteoporosis, Malignant gastrointestinal stromal tumours, Prevention & risk reduction of invasive breast cancer Administration: May be taken with or without food. Adult Dose: Oral Prophylaxis of postmenopausal osteoporosis; Osteoporosis in postmenopausal women Adult: 60 mg once daily. Breast Cancer Prevention; risk reduction of invasive breast cancer in postmenopausal women at high risk for invasive breast cancer 60 mg PO qDay for 5 years Hepatic impairment: Contraindicated. Renal Dose: Renal impairment: Severe: Contraindicated. Contraindication: Active or history of venous thromboembolic events including DVT, pulmonary embolism, retinal vein thrombosis. Unexplained uterine bleeding. Patients w/ signs/symptoms of endometrial cancer. Hepatic (including cholestasis) and severe renal impairment. Pregnancy, women who may become pregnant, and lactation. Mode of Action: Raloxifene is a selective oestrogen receptor modulator that has both selective agonist or antagonist activities on oestrogen receptors. It acts as an agonist on bone by preventing bone loss and partially on cholesterol metabolism by decreasing total and LDL cholesterol levels but antagonises oestrogen effects leading to development of breast and uterine cancer. Precaution: Women w/ risk factors for venous thromboembolism including CHF or active malignancy, risk factors for stroke (e.g. TIA, AF), history of oestrogen-induced hypertriglyceridaemia. Moderate renal impairment. Monitoring Parameters Monitor serum triglyceride concentration. Lactation: Excretion in milk unknown; contraindicated Side Effect: >10% Hot flashes (8-29%),Flu syndrome (14-15%),Cramps/muscle spasm (6-12%),Arthralgia (11-16%),Infection (11%) 1-10% Insomnia (6%),Vomiting (5%),Sinusitis (10%),Venous thromboembolism (1-2% ),Bronchitis (10%),Pharyngitis (8%),Breast pain (4%),Gastroenteritis (<3%),Diaphoresis (3%) Frequency Not Defined Deep vein thrombosis,Cerebrovascular accident,Thrombosis of retinal vein (rare),Pulmonary embolism,Decreased fibrinogen Interaction: Cholestyramine reduces the absorption of raloxifene. Raloxifene with warfarin may reduce the prothrombin response and time. Caution when used in hghly protein-bound drugs such as diazepam, lidocaine and diazoxide.