Adagel Plus Gel - Gel Adapalene 0.1% + Benzoyl Peroxide 2.5% - 0.1% + 2.5% 1 20gm tube(s) / 20gm tube Unimed Unihealth Pharmaceuticals Ltd. Introduction: Adagel Plus Gel is a prescription medicine having combination of medicines that are used to treat acne. It removes the dead layer of the skin which is present on the top. It stops the growth of bacteria. Adagel Plus Gel should be used in the dose and duration as advised by your doctor. It is for external use only. Wash your hands before using this medicine. Apply only on the affected areas of the skin. It is advised to check the label for directions before use. The most common side effects include skin irritation, itchiness and burning, and sensation at... Uses of Adagel Plus Gel: Acne Side effects of Adagel Plus Gel: Skin peelingSkin irritationDry skinBurning sensation at the site of applicationErythema (skin redness) How to use Adagel Plus Gel: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area. How Adagel Plus Gel works: Adagel Plus Gel is a combination of two medicines: Adapalene and Benzoyl Peroxide, which treats acne (pimples). Adapalene is a form of vitamin A and Benzoyl Peroxide is a keratolytic medicine. Together, they prevent accumulation of the sebum (skin’s natural oil), unblock the pores and allow natural exfoliation of the outer layers of skin. Benzoyl Peroxide additionally penetrates into the skin and kills acne-causing bacteria. Indication: Apply a thin film of adapalene and benzoyle peroxide gel to affected areas of the face and/or trunk once daily after washing. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek). Avoid the eyes, lips and mucous membranes. Administration: Adapalene: Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents. Benzoyl Peroxide: PABA sunscreens may transiently discolour fabric. Adult Dose: Exposure to sunlight, including sunlamps, should be minimized during the use of adapalene and benzoyle peroxide gel. Patients with high levels of sun exposure and those with inherent sensitivity to sun should exercise particular caution. Use of sunscreen products and protective apparel, (e.g., hat) are recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, may be irritating to patients under treatment with adapalene and benzoyle peroxide gel. Safety and effectiveness of Adapalene and Benzoyl peroxide gel in pediatric patients under the age of 9 years have not been established. Renal Dose: Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Benzoyl peroxide has mild keratolytic effect and antimicrobial activity which is attributed to its oxidative property. It is active against S.epidermidis and P.acne. Contraindication: Child: >9 years: Apply thin film to affected facial areas and/or trunk qPM after washing <9 years: Safety & efficacy has not been established. Precaution: Acne Pregnancy Category Note: >10% Stinging/ burning (3-41%),Dryness (1-41%),Scaling (1-35%),Erythema (1-27%) 1-10% Contact dermatitis (3%),Application site burning (2%),Application site irritation (1%),Skin irritation (1%) Interaction: Hypersensitive to any of the components.