Acliz - Tablet Meclizine Hydrochloride - 50mg 10 Tablet(s) / Strip Aristopharma Limited Introduction: Acliz is an antihistamine medicine used to treat nausea, vomiting and vertigo associated with motion sickness. Acliz should be taken with or without food, but take it at the same time every day to get the most benefit. If you are travelling, then take it one hour before travelling. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. In... Uses of Acliz: Motion sicknessVertigo Side effects of Acliz: Sleepiness How to use Acliz: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Acliz may be taken with or without food, but it is better to take it at a fixed time. How Acliz works: Acliz is an antihistaminic medication. It works by blocking the action of histamine, a chemical in the brain that controls nausea, vomiting, and balance. It also makes you sleepy. What if you forget to take Acliz?: If you miss a dose of Acliz, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Indication: Motion sickness, Vertigo and Vestibular disorders Administration: May be taken with or without food. Adult Dose: Oral Motion sickness Adult: 25-50 mg 1 hr before travelling and repeat 24 hrly if needed. Vertigo and vestibular disorders Adult: 25-100 mg daily in divided doses. Discontinue if there is no response after 1-2 wk of treatment. Nausea and vomiting 25-50 mg daily Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment. Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP) : 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours. Child Dose: Oral 12 years: 12.5-50 mg PO given 1 hour before travel and then daily PRN Vertigo >12 years: 25-100 mg/day PO in single daily dose or divided q6-12hr Contraindication: Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients. Mode of Action: Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways. Precaution: Patients should be warned that Meclizine Hydrochloride may impair their ability to perform hazardous activities requiring mental alertness or physical coordination (e.g., operating machinery, driving a motor vehicle). Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland. Lactation: Not known if excreted in milk; use caution Side Effect: Headache, drowsiness, vomiting, dry mouth, fatigue. Rarely, blurred vision. Interaction: Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.