Ace Plus - Tablet Paracetamol + Caffeine - 65mg+500mg 10 Tablet(s) / Strip Square Pharmaceuticals PLC. Introduction: Ace Plus is a combination of two medicines used in the treatment of headache. It helps relieve headache by blocking the release of certain chemical messengers that causes headache. Your doctor will advise how much Ace Plus you need to take. It can be taken with or without food. You should take the medicine regularly while you do need it and try not to miss doses as it will become less effective. It should be used with caution in people who have any problems with their heart, kidneys, or liver. Using this medicine may cause increased heart rate or restlessness.... Uses of Ace Plus: Headache Side effects of Ace Plus: Increased heart rateRestlessness How to use Ace Plus: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ace Plus may be taken with or without food, but it is better to take it at a fixed time. Avoid Ace Plus with caffeine and chocolate as well as food containing caffeine and chocolate such as tea leaves, cocoa beans. How Ace Plus works: Ace Plus is a combination of two medicines: Caffeine and Paracetamol/Acetaminophen. Caffeine narrows the blood vessels in the brain to reduce headache. Paracetamol/Acetaminophen is an analgesic (pain reliever) which works by blocking the release of certain chemical messengers that cause pain. Together, they relieve headache effectively.