A-Clox 500 - Capsule Cloxacillin - 500mg 4 Capsule(s) / Strip The ACME Laboratories Ltd. Introduction: A-Clox 500 is an antibiotic used to treat various bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract, and skin and soft tissue. It mainly fights and stops the growth of the gram-positive type of bacteria. A-Clox 500 should be taken on an empty stomach. For best results, it should be used regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. Do not skip any doses and finish the full course of treatment even... Uses of A-Clox 500: Bacterial infections Side effects of A-Clox 500: RashVomitingAllergic reactionNauseaDiarrhea How to use A-Clox 500: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. A-Clox 500 is to be taken empty stomach. How A-Clox 500 works: A-Clox 500 is an antibiotic. It kills bacteria by preventing them from forming their own protective covering (cell wall) which is needed for them to survive. Indication: Staphylococcal infections resistant to benzylpenicillin Administration: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals. Reconstitution: IM: The contents of each vial should be dissolved in 1.5 mL of water for inj. IV: 500 mg to be dissolved in 10-20 mL of water for inj, added to suitable IV fluids if given for i Adult Dose: Oral Adult: 250-500 mg 4 times/day. Parenteral Adult: 1-2 g 6 hrly. For more severe infections (e.g. meningitis, endocarditis), 2 g 4 hrly. Child Dose: Oral Child: 50-100 mg/kg in divided doses every 6 hr. Contraindication: Hypersensitivity to cloxacillin and other penicillins. Mode of Action: Cloxacillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested. Precaution: Patient w/ allergies esp β-lactam allergy, asthma, history of seizure disorder. Renal impairment. Pregnancy and lactation. Monitoring Parameters Observe for signs and symptoms of anaphylaxis during 1st dose. Monitor CBC w/ differential (prior to initiating therapy and wkly thereafter), periodic BUN, creatinine, hepatic function. Side Effect: Hypotension, confusion, fever, lethargy, seizure, pruritus, rash, urticaria, abdominal pain, black or hairy tongue, diarrhoea, flatulence, nausea, oral candidiasis, pseudomembranous colitis, stomatitis, vomiting, agranulocytosis, bone marrow depression, eosinophilia, granulocytopenia, haemolytic anaemia, leucopenia, neutropenia, thrombocytopenia, increased alkaline phosphatase, ALT and AST, hepatotoxicity, thrombophlebitis, arthralgia, myalgia, myoclonus, hematuria, interstitial nephritis, proteinuria, renal insufficiency, renal tubular damage, bronchospasm, laryngeal oedema, laryngospasm, sneezing, wheezing, angioedema, allergic reaction, serum sickness-like reaction. Potentially Fatal: Anaphylaxis. Interaction: May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time w/ anticoagulants. Increased serum concentrations w/ probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.