5-Fluril 250 - Injection 5-Fluorouracil (5-FU) - 250mg/10ml 1 250mg vial(s) / 250mg vial EDCL Introduction: 5-Fluril 250 is used in the treatment of cancers of stomach, colon, rectum, breast, and lungs. It may be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy. 5-Fluril 250 is given as injection under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the... Uses of 5-Fluril 250: Cancer Side effects of 5-Fluril 250: Increased risk of infectionMouth ulcerVomitingWeaknessNauseaLoss of appetiteHair lossBlisters on fingers/feetDecreased blood cells (red cells, white cells, and platelets)Diarrhea How to use 5-Fluril 250: Your doctor or nurse will give you this medicine. Kindly do not self administer. How 5-Fluril 250 works: 5-Fluril 250 is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them. Indication: Palliation of malignant neoplasms, Superficial basal cell carcinoma, Oesophageal carcinoma, Carcinoma of Colon, Carcinoma of Breast, Carcinoma of Ovary, Carcinoma of Liver, Carcinoma of Pancreas, Carcinoma of Rectum, Carcinoma of Stomach Administration: IV Preparation IV Push: dose/syringe (concentration: 50 mg/mL); max syringe size for IVP is 30 mL syringe and syringe should be <75% full Continuous IV Infusion/IVPB: dose/50-1000 mL D5W or NS; syringe and solution are stable for 72 hr at 4 to 25°C IV Administration Direct IV push injection (50 mg/mL solution needs no further dilution) or by IV infusion Toxicity may be reduced by giving the drug as a constant infusion Bolus doses may be administered by slow IVP or IVPB Warm to body temperature before using Continuous IV infusion may be administered in D5W or NS Solution should... Adult Dose: Adult: IV Palliation of malignant neoplasms 12 mg/kg/day (max: 0.8-1g/day) for 3-4 days, if no toxicity occurs, may be followed after 1 day w/ 6 mg/kg on alternate days for another 3-4 doses. May repeat course 4-6 wk later or maintenance doses of 5-15 mg/kg (max: 1 g) may be given wkly. Cancers of Colon, Breast, Ovary, Liver, Pancreas, Rectum, Stomach Various protocols exist 500 mg/sq.meter IV on Days 1-5, OR 450-600 mg/sq.meter IV weekly, OR 200-400 mg/sq.meter IV continuous infusion qD Not to exceed 800 mg/day As an infusion: 15 mg/kg/day (max: 1 g/day), continue until toxicity occurs or... Child Dose: Child: Safety & efficacy not established. Renal Dose: Renal impairment: Dose reduction may be required. Contraindication: Topical application on mucous membranes, exposure to sunlight, hypersensitivity. Depressed bone marrow function, poor nutritional status, potentially serious infections. Pregnancy and lactation. Mode of Action: Fluorouracil interferes with DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid. It also interferes with RNA synthesis. This results in an unbalanced growth of the cells. Fluorouracil exerts greater effect on rapidly growing cells as they take up the drug at a faster rate. Precaution: Regular monitoring of blood counts. History of heart disease, hepatic or renal insufficiency, weak or malnourished patients, patients who with history of high-dose pelvic radiation or use of alkylating agents. Patients with widespread metastases to the bone marrow. Lactation: excretion in milk unknown; do not nurse. Side Effect: 1-10% Loss of appetite,Headache,Nausea,Vomiting,Diarrhea,Mucositis,Myelosuppression,Alopecia,Photosensitivity,Hand-foot syndrome,Maculopapular eruption (pruritic) Frequency Not Defined Angina,Coronary arteriosclerosis,Thrombophlebitis,Darkening of veins,Gastrointestinal ulcer,Increased alkaline phosphatase,Increased LFTs,Hyperbilirubinemia,Hypercholesterolemia (increased LDH),Anaphylaxis,Nystagmus,Ophthalmic findings Potentially Fatal: Central neurotoxicity, myocardial ischaemia. Pregnancy Category Note: Pregnancy Category: D Risk Summary There are no adequate and well-controlled studies with fluorouracil in pregnant women. Based on its mechanism of action, fluorouracil can cause fetal harm when administered to a pregnant woman. Lactation: excretion in milk unknown; do not nurse Interaction: May increase warfarin effects. May reduce response to vaccines; possibility of generalized infection with live vaccines. Action may be modified by allopurinol. Leucovorin calcium may enhance the toxicity of fluorouracil.